A Study on the Relationship Between Daeseunggi-tang and Sepsis

Ju-Hyun Lee; Eun-Heui Jo; Min-Cheol Park; Lee, Ju-Hyun; Jo, Eun-Heui; Park, Min-Cheol

doi:10.13048/jkm.23029

JKM > Volume 44(3); 2023 > Article

Lee, Jo, and Park: A Study on the Relationship Between Daeseunggi-tang and Sepsis

Original Article

The Journal of Korean Medicine 2023; 44(3): 39-46.

Published online: September 1, 2023

DOI: https://doi.org/10.13048/jkm.23029

A Study on the Relationship Between Daeseunggi-tang and Sepsis

Ju-Hyun Lee¹

, Eun-Heui Jo²^{, 3}^{, *}

, Min-Cheol Park³^{, 4}^{, *}

¹Department of Medical Support, Imsil-gun Medical Center, Imsil, Jeollabuk-do, Republic of Korea

²Department of Acupuncture and Moxibustion, Wonkwang University Korean Medicine Hospital, Deokjingu, Jeonju, Jeollabuk-do, Republic of Korea

³Research Center of Traditional Korean Medicine, Wonkwang University, Iksan, Jeollabuk-do, Republic of Korea

⁴Department of Korean Medicine Ophthalmology, Otolaryngology and Dermatology, Wonkwang University Korean Medicine Hospital, Iksan, Jeollabuk-do, Republic of Korea

Correspondence to: Eun-Heui Jo, Department of Acupuncture & Moxibustion Medicine, Wonkwang University Korean Medicine Hospital, 99, Garyeonsan-ro, Deokjin-gu, Jeonju-si, Jeollabuk-do, 54887, Republic of Korea, Tel: +82-63-270-1022, Fax: +82-63-270-1199, E-mail: freezo@wonkwang.ac.kr

Correspondence to: Min-Cheol Park Department of Korean Medicine Ophthalmology, Otolaryngology and Dermatology, Wonkwang University Korean Medicine Hospital, 895 Muwang-ro, Iksan-si, Jeollabuk-do, 54538, Republic of Korea Tel：+82-63-859-2821, Fax: +82-63-841-0033, E-mail: spinx11@wonkwang.ac.kr

Received April 26, 2023 Revised June 19, 2023 Accepted July 18, 2023

Abstract

Objectives

This research aims to analyze the relationship between Daeseunggi-tang and sepsis in literature.

Methods

The main treatment symptoms of Daeseunggi-tang presented in Sanghanron and GeumGweyoryak, the symptoms of Ju-hwang and Nae-ham which correspond to sepsis in Korean Medicine, the symptoms of sepsis presented in the related papers including international guideline and diagnosis criteria of spesis were compared and analyzed.

Results

The main treatment symptoms of Daeseunggi-tang were very similar to the symptoms of sepsis, and were almost identical to the symptoms of Ju-hwang and Nae-ham (especially Hwa-ham, Gu-ham), which are the Korean medicine descriptions of sepsis.

Conclusions

Based on the above research results, it seems to be possible to use Daeseunggi-tang for the treatment of sepsis.

Keywords: Literature Study, Daeseunggi-tang, Sepsis, Traditional Medicine

Table 1

Statements Related to Daeseunggi-tang

傷寒論	208. 陽明病脈遲雖汗出不惡寒者其身必重短氣腹滿而喘有潮熱者此外欲解可攻裏也手足濈然汗出者此大便已硬也大承氣湯主之若汗多微發熱惡寒者外未解也其熱不潮未可與承氣湯若腹大滿不通者可與小承氣湯微和胃氣勿令至大泄下
	209. 陽明病潮熱大便微硬者可與大承氣湯不硬者不可與之若不大便六七日恐有燥屎欲知之法少與小承氣湯湯入腹中轉失氣者此有燥屎也乃可攻之若不轉失氣者此但初頭硬後必溏不可攻之攻之必脹滿不能食也欲飮水者與水則噦其後發熱者必大便復硬而少也以小承氣湯和之不轉失氣者愼不可攻也
	212. 傷寒若吐若下後不解不大便五六日上至十餘日日晡所發潮熱不惡寒獨語如見鬼狀若劇者發則不識人循衣摸床惕而不安微喘直視脈弦者生澁者死微者但發熱譫語者大承氣湯主之若一服利則止後腹
	215. 陽明病譫語有潮熱反不能食者胃中必有燥屎五六枚也若能食者但硬耳宜大承氣湯下之
	217. 汗出譫語者以有燥屎在胃中此爲風也須下者過經乃可下之下之若早譫語必亂以表虛裏實故也下之愈宜大承氣湯
	220. 二陽幷病太陽證罷但發潮熱手足漐漐汗出大便難而譫語者下之則愈宜大承氣湯
	238. 陽明病下之心中懊憹而煩胃中有燥屎者可攻腹微滿初頭硬後必溏不可攻之若有燥屎者宜大承氣湯
	239. 病人不大便五六日繞臍痛煩躁發作有時者此有燥屎故使不大便也
	240. 病人煩熱汗出則解又如瘧狀日晡所發熱者屬陽明也脈實者宜下之脈浮虛者宜發汗下之與大承氣湯發汗宜桂枝湯
	241. 大下後六七日不大便煩不解腹滿痛者此有燥屎也所以然者本有宿食故也宜大承氣湯
	242. 病人小便不利大便乍難乍易時有微熱喘冒不能臥者有燥屎也宜大承氣湯
	251. 得病二三日脈弱無太陽柴胡證煩燥心下硬至四五日雖能食以小承氣湯少少與微和之令小安至六日與承氣湯一升若不大便六七日小便少者雖不受食但初頭硬後必溏未定成硬攻之必溏須小便利屎定硬乃可攻之宜大承氣湯
	252. 傷寒六七日目中不了了睛不和無表裏證大便難身微熱者此爲實也急下之宜大承氣湯
	253. 陽明病發熱汗多者急下之宜大承氣湯
	254. 發汗不解腹脹滿痛者急下之宜大承氣湯
	255. 腹滿不減減不足言當下之宜大承氣湯
	256. 陽明少陽合病必下利其脈不負者爲順也負者失也互相剋賊名曰負也脈滑而數者有宿食也當下之宜大承氣湯
	320. 少陰病得之二三日嘔燥咽乾者急下之宜大承氣湯
	321. 少陰病自利淸水色純靑心下必痛口乾燥者可下之宜大承氣湯
	322. 少陰病六七日腹脹不大便者急下之宜大承氣湯
金匱要略	2–13. 痙爲病, 一本痙字上有剛字. 胸滿, 口噤, 臥不着席, 脚攣急, 必齘齒, 可與大承氣湯.
	10–13. 腹滿不減, 減不足言, 當須下之, 宜大承氣湯.
	10–21. 問曰: 人病有宿食, 何以別之? 師曰: 寸口脈浮而大, 按之反澁, 尺中亦微而澁, 故知有宿食, 大承氣湯主之.
	10–22. 脈數而滑者, 實也, 此有宿食, 下之愈, 宜大承氣湯.
	10–23. 下利不欲食者, 有宿食也, 當下之, 宜大承氣湯.
	17–37. 下利三部脈皆平, 按之心下堅者, 急下之, 宜大承氣湯.
	17–38. 下利脈遲而滑者, 實也, 利未欲止, 急下之, 宜大承氣湯.
	17–39. 下利脈反滑者, 當有所去, 下乃愈, 宜大承氣湯.
	17–40. 下利已差, 至其年月日時復發者, 以病不盡故也, 當下之, 宜大承氣湯.
	21-3. 病解能食, 七八日更發熱者, 此爲胃實, 大承氣湯主之.方見痙病中.
	21-7. 産後七八日, 無太陽證, 少腹堅痛, 此惡露不盡; 不大便, 煩躁發熱, 切脈微實, 再倍發熱, 日哺時煩躁者, 不食, 食則譫語, 至夜卽愈, 宜大承氣湯主之. 熱在裏結在膀胱也. 方見痙病中.

Table 2

Symptoms of Ju-hwang and Nae-ham

走黃	① 傳心: 神志昏糊, 煩躁, 譫語, 斑疹, 血尿, 流注, 附骨疽
	② 傳肺: 胸悶, 氣急, 咳嗽, 喀血, 聲嘶, 咽乾
	③ 傳肝: 四肢抽搐, 角弓反張, 上視
	④ 傳脾: 脘悶, 惡心, 便祕, 腹瀉, 黃疸
	⑤ 傳腎: 目暗睛露, 四肢厥冷, 小便不禁

內陷	① 火陷證: 發熱, 口渴, 便祕, 尿赤, 煩躁, 神昏, 纖語, 脇肋部痛
	② 乾陷證: 發熱, 惡寒, 神疲, 譫語, 氣息, 粗促 / 肢冷, 大便溏薄, 小便頻數
	③ 虛陷證: 虛熱, 形神萎頓, 納食日減, 腹痛便泄, 自汗肢冷, 昏迷厥脫,

Table 3

Diagnostic Criteria for Sepsis

International Criteria for Sepsis	qSOFA	Respiratory Rate ≧ 22/min Systolic Blood Pressure ≥ 100 mmHg Acute Disturbance of Consciousness
International Criteria for Sepsis	SIRS	Body Temperature > 38 °C or < 36 °C Heart Rate > 90/min Respiratory Rate > 20/min or PaCO2 < 32 mmHg White Blood Cell > 12,000 μL or < 4,000 μL Eosinophil > 10 %

* qSOFA: Quick Sequential Organ Failure Assessment; SIRS: Systemic Inflammatory Response Syndrome; PaCO2: Partial Pressure of Arterial Carbon Dioxide

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