A Study on the Relationship Between Daeseunggi-tang and Sepsis

Article information

J Korean Med. 2023;44(3):39-46
Publication date (electronic) : 2023 September 1
doi : https://doi.org/10.13048/jkm.23029
1Department of Medical Support, Imsil-gun Medical Center, Imsil, Jeollabuk-do, Republic of Korea
2Department of Acupuncture and Moxibustion, Wonkwang University Korean Medicine Hospital, Deokjingu, Jeonju, Jeollabuk-do, Republic of Korea
3Research Center of Traditional Korean Medicine, Wonkwang University, Iksan, Jeollabuk-do, Republic of Korea
4Department of Korean Medicine Ophthalmology, Otolaryngology and Dermatology, Wonkwang University Korean Medicine Hospital, Iksan, Jeollabuk-do, Republic of Korea
Correspondence to: Eun-Heui Jo, Department of Acupuncture & Moxibustion Medicine, Wonkwang University Korean Medicine Hospital, 99, Garyeonsan-ro, Deokjin-gu, Jeonju-si, Jeollabuk-do, 54887, Republic of Korea, Tel: +82-63-270-1022, Fax: +82-63-270-1199, E-mail: freezo@wonkwang.ac.kr
Correspondence to: Min-Cheol Park Department of Korean Medicine Ophthalmology, Otolaryngology and Dermatology, Wonkwang University Korean Medicine Hospital, 895 Muwang-ro, Iksan-si, Jeollabuk-do, 54538, Republic of Korea Tel:+82-63-859-2821, Fax: +82-63-841-0033, E-mail: spinx11@wonkwang.ac.kr
Received 2023 April 26; Revised 2023 June 19; Accepted 2023 July 18.

Abstract

Objectives

This research aims to analyze the relationship between Daeseunggi-tang and sepsis in literature.

Methods

The main treatment symptoms of Daeseunggi-tang presented in Sanghanron and GeumGweyoryak, the symptoms of Ju-hwang and Nae-ham which correspond to sepsis in Korean Medicine, the symptoms of sepsis presented in the related papers including international guideline and diagnosis criteria of spesis were compared and analyzed.

Results

The main treatment symptoms of Daeseunggi-tang were very similar to the symptoms of sepsis, and were almost identical to the symptoms of Ju-hwang and Nae-ham (especially Hwa-ham, Gu-ham), which are the Korean medicine descriptions of sepsis.

Conclusions

Based on the above research results, it seems to be possible to use Daeseunggi-tang for the treatment of sepsis.

Statements Related to Daeseunggi-tang

Symptoms of Ju-hwang and Nae-ham

Diagnostic Criteria for Sepsis

References

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Article information Continued

Table 1

Statements Related to Daeseunggi-tang

傷寒論 208. 陽明病 脈遲 雖汗出 不惡寒者 其身必重 短氣 腹滿而喘 有潮熱者 此外欲解 可攻裏也 手足濈然汗出者 此大便已硬也大承氣湯主之 若汗多 微發熱惡寒者 外未解也 其熱不潮 未可與承氣湯 若腹大滿不通者 可與小承氣湯 微和胃氣勿令至大泄下
209. 陽明病 潮熱 大便微硬者 可與大承氣湯 不硬者 不可與之 若不大便 六七日 恐有燥屎 欲知之法 少與小承氣湯 湯入腹中轉失氣者 此有燥屎也 乃可攻之 若不轉失氣者 此但初頭硬 後必溏 不可攻之 攻之必脹滿 不能食也 欲飮水者 與水則噦 其後發熱者 必大便復硬而少也 以小承氣湯 和之 不轉失氣者 愼不可攻也
212. 傷寒 若吐若下後 不解 不大便 五六日 上至十餘日 日晡所發潮熱 不惡寒 獨語 如見鬼狀 若劇者 發則不識人 循衣摸床惕而不安 微喘直視 脈弦者生 澁者死 微者但發熱 譫語者 大承氣湯主之 若一服利 則止後腹
215. 陽明病 譫語 有潮熱 反不能食者 胃中必有燥屎五六枚也 若能食者 但硬耳 宜大承氣湯下之
217. 汗出譫語者 以有燥屎 在胃中 此爲風也 須下者過經 乃可下之 下之若早 譫語必亂 以表虛裏實故也 下之愈 宜大承氣湯
220. 二陽幷病 太陽證罷 但發潮熱 手足漐漐汗出 大便難而譫語者 下之則愈 宜大承氣湯
238. 陽明病 下之 心中懊憹而煩 胃中有燥屎者 可攻 腹微滿 初頭硬 後必溏 不可攻之 若有燥屎者 宜大承氣湯
239. 病人 不大便 五六日 繞臍痛 煩躁發作有時者 此有燥屎 故使不大便也
240. 病人煩熱 汗出則解 又如瘧狀 日晡所發熱者 屬陽明也 脈實者 宜下之 脈浮虛者 宜發汗 下之 與大承氣湯 發汗 宜桂枝湯
241. 大下後六七日 不大便 煩不解 腹滿痛者 此有燥屎也 所以然者 本有宿食故也 宜大承氣湯
242. 病人 小便不利 大便乍難乍易 時有微熱 喘冒不能臥者 有燥屎也 宜大承氣湯
251. 得病二三日 脈弱 無太陽柴胡證 煩燥 心下硬 至四五日 雖能食 以小承氣湯少少與 微和之 令小安 至六日 與承氣湯一升若不大便 六七日 小便少者 雖不受食 但初頭硬 後必溏 未定成硬 攻之必溏 須小便利 屎定硬 乃可攻之 宜大承氣湯
252. 傷寒六七日 目中不了了 睛不和 無表裏證 大便難 身微熱者 此爲實也 急下之 宜大承氣湯
253. 陽明病 發熱汗多者 急下之 宜大承氣湯
254. 發汗不解 腹脹滿痛者 急下之 宜大承氣湯
255. 腹滿不減 減不足言 當下之 宜大承氣湯
256. 陽明少陽合病 必下利 其脈不負者爲順也 負者失也 互相剋賊 名曰負也 脈滑而數者 有宿食也 當下之 宜大承氣湯
320. 少陰病 得之 二三日 嘔燥咽乾者 急下之 宜大承氣湯
321. 少陰病 自利淸水 色純靑 心下必痛 口乾燥者 可下之 宜大承氣湯
322. 少陰病 六七日 腹脹 不大便者 急下之 宜大承氣湯
金匱要略 2–13. 痙爲病, 一本痙字上有剛字. 胸滿, 口噤, 臥不着席, 脚攣急, 必齘齒, 可與大承氣湯.
10–13. 腹滿不減, 減不足言, 當須下之, 宜大承氣湯.
10–21. 問曰: 人病有宿食, 何以別之? 師曰: 寸口脈浮而大, 按之反澁, 尺中亦微而澁, 故知有宿食, 大承氣湯主之.
10–22. 脈數而滑者, 實也, 此有宿食, 下之愈, 宜大承氣湯.
10–23. 下利不欲食者, 有宿食也, 當下之, 宜大承氣湯.
17–37. 下利三部脈皆平, 按之心下堅者, 急下之, 宜大承氣湯.
17–38. 下利脈遲而滑者, 實也, 利未欲止, 急下之, 宜大承氣湯.
17–39. 下利脈反滑者, 當有所去, 下乃愈, 宜大承氣湯.
17–40. 下利已差, 至其年月日時復發者, 以病不盡故也, 當下之, 宜大承氣湯.
21-3. 病解能食, 七八日更發熱者, 此爲胃實, 大承氣湯主之.方見痙病中.
21-7. 産後七八日, 無太陽證, 少腹堅痛, 此惡露不盡; 不大便, 煩躁發熱, 切脈微實, 再倍發熱, 日哺時煩躁者, 不食, 食則譫語, 至夜卽愈, 宜大承氣湯主之. 熱在裏 結在膀胱也. 方見痙病中.

Table 2

Symptoms of Ju-hwang and Nae-ham

走黃 ① 傳心: 神志 昏糊, 煩躁, 譫語, 斑疹, 血尿, 流注, 附骨疽
② 傳肺: 胸悶, 氣急, 咳嗽, 喀血, 聲嘶, 咽乾
③ 傳肝: 四肢抽搐, 角弓反張, 上視
④ 傳脾: 脘悶, 惡心, 便祕, 腹瀉, 黃疸
⑤ 傳腎: 目暗睛露, 四肢厥冷, 小便不禁

內陷 ① 火陷證: 發熱, 口渴, 便祕, 尿赤, 煩躁, 神昏, 纖語, 脇肋部痛
② 乾陷證: 發熱, 惡寒, 神疲, 譫語, 氣息, 粗促 / 肢冷, 大便溏薄, 小便頻數
③ 虛陷證: 虛熱, 形神萎頓, 納食日減, 腹痛便泄, 自汗肢冷, 昏迷厥脫,

Table 3

Diagnostic Criteria for Sepsis

International Criteria for Sepsis qSOFA Respiratory Rate ≧ 22/min
Systolic Blood Pressure ≥ 100 mmHg
Acute Disturbance of Consciousness
SIRS Body Temperature > 38 °C or < 36 °C
Heart Rate > 90/min
Respiratory Rate > 20/min or PaCO2 < 32 mmHg
White Blood Cell > 12,000 μL or < 4,000 μL
Eosinophil > 10 %
*

qSOFA: Quick Sequential Organ Failure Assessment; SIRS: Systemic Inflammatory Response Syndrome; PaCO2: Partial Pressure of Arterial Carbon Dioxide