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JKM > Volume 37(1); 2016 > Article
Lee and Choi: The Safety and Efficacy of Herbal Medicine for 107 Psoriasis Patients: A Retrospective Chart Review



To observe safety and efficacy of herbal medicine for psoriasis patients.


We did retrospective chart review for 107 psoriasis patients who had been treated by herbal medicine for 2 months, and we analyzed the liver function test (LFT) results and Psoriasis Area and Severity Index (PASI) scores of before and after the treatment.


The mean LFT and the number of patients with abnormal LFT decreased after the treatments. More than 95% of patients with normal LFT maintained normal results at after the treatment, and only 2.1% and 4.6% patients with normal LFT showed abnormal Glutamic Oxaloacetic Transaminase (GOT) and Glutamic Pyruvic Transaminase (GPT) results at after the treatment. Also, both mean PASI scores for all patients and patients with abnormal LFT before the treatment decreased significantly.


This study suggest that herbal medicine may be safe and effective treatment for psoriasis.

Table 1.
The Compositions of Gamibangpungtongseoung-san
Scientific name of herbs Dose(grams)
Talcum 6.8
Glycyrrhizae Radix 4.8
Gypsum Fibrosum 2.8
Scutellariae Radix 2.8
Platycodi Radix 2.8
Ledebouriellae Radix 1.8
Paeonia Radix Rubra 1.8
Cnidium officinale 1.8
Angelicae gigantis Radix 1.8
Rhei Rhizoma 1.8
Menthae Herba 1.8
Forsythiae Fructus 1.8
Natrii Sulfas 1.8
Schizonepetae Herba 1.4
Atractylodis Macrocephalae Rhizoma 1.4
Gardeniae Fructus 1.4
Astragalus membranaceus 12.0
Coptis chinensis 4.0
Table 2.
Baseline Characteristics of Subjects
N (Male/Female) Age Body weight (kg) Treatment months
107 (59/48) 33.2±11.6 66.6±14.2 11.6±11.1

The values given are the mean±SD.

Table 3.
GOT, GPT Value and Number of Abnormal Patients
Before treatment After treatment
GOT Mean±SD(IU/L) 32.73±30.25 25.92±10.21
Number of abnormal patients (% of total patients) 13(12.2) 7(6.5)

GPT Mean±SD(IU/L) 29.01±30.96 21.08±14.12
Number of abnormal patients (% of total patients) 20(18.7) 8(7.5)

GOT: glutamic oxaloacetic transaminase; GPT: glutamic pyruvic transaminase; SD: standard deviation

Table 4.
Distributions of the Patients by GOT Test
After treatment Total

Normal Abnormal
Before treatment (n, %) Normal 92(97.9) 2(2.1) 94(100)
Abnormal 8(61.5) 5(38.5) 13(100)
Total (n) 100 7 107

GOT: glutamic oxaloacetic transaminase

Table 5.
Distributions of the Patients by GPT Test
After treatment Total

Normal Abnormal
Before treatment (n, %) Normal 83(95.4) 4(4.6) 87(100)
Abnormal 16(80.0) 4(20.0) 20(100)
Total (n) 99 8 107

GPT: glutamic pyruvic transaminase

Table 6.
Change of PASI Score
Before treatment After treatment p-value
PASI (107 patients) 13.45±7.99 3.29±4.47 0.000**
PASI (22 patients) 14.23±6.19 4.06±5.30 0.000**

The values given are the mean±SD. Statistical significance was set at a P value < 0.05, using paired t-test for PASI score of all patients and Wilcoxon signed rank test for PASI score of 22 patients.

PASI: Psoriasis Area and Severity Index;

** p<0.01.


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