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JKM > Volume 39(3); 2018 > Article
Lee, Woo, Park, Hwang, Lee, Jang, and Lee: Two Case Report of Obesity with atopic dermatitis Treated with Hwangryunhaedoktang-gamibang



This study was performed1 to assess the effectiveness of HwangryunHaedokTang-gamibang on Obesity with atopic dermatitis.


Patients were treated by HwangryunHaedokTang-gamibang. To measure treatment outcomes, BMI, weight, Fat mass, Fat %, VAS scale, SCORAD index were used.


After treatment, BMI, weight, Fat mass, Fat% were significantly decreased. Atopic dermatitis VAS and SCORAD index were also decreased at all cases.


HwangryunHaedokTang-gamibang may be effective in the treatment of Obesity with atopic dermatitis patients.

Table 1
Composition of HwangryunHaedokTang-gamibang I and II
Prescription 黃連解毒湯加味方I 黃連解毒湯加味方II
Composition 薏苡仁 12g
黃連 黃芩 黃柏 梔子 各 5g 黃連 黃芩 黃柏 梔子 各 5g
葛根 白芍藥 升麻 甘草 玄 葛根 白芍藥 升麻 甘草 玄
蔘 荊芥 防風 蟬退 各 蔘 荊芥 防風 蟬退 各
2.625g 2.625g
Table 2
The Progress of Treatment(Case 1)
Visit Progress Prescription
Body Weight (kg) BMI (kg/m2) FAT percent FAT mass (kg) VAS of Pruritus SCORAD index
1st visit
62.3 24.0 30.4% 18.9 VAS 8 47.3 黃連解毒湯加味方I
2nd visit
60.0 23.1 28.3% 17.0 VAS 5 24.3 黃連解毒湯加味方I
3rd visit
57.2 22.1 27.1% 15.5 VAS 3 7.6 黃連解毒湯加味方I
4th visit
57.5 22.2 27.2 % 15.6 - 3.7 黃連解毒湯加味方II
Table 3
The Progress of Treatment(Case 2)
Visit Progress Prescription
Body Weight (kg) BMI (kg/m2) FAT% FAT mass (kg) VAS of Pruritus (Face/finger) SCORAD index
1st visit
67.9 24.6 33.0% 22.4 VAS 10/VAS 10 87.7 黃連解毒湯加味方I
2nd visit
65.0 23.6 32.6% 21.2 VAS 7/VAS 6 70.3 黃連解毒湯加味方I
3rd visit
64.1 23.3 30.7% 19.7 VAS 5/VAS 3 47 黃連解毒湯加味方II


1. Statistics Korea. Experiences of atopic dermatitis diagnosis: sex, age 19 and over. Korean Statistical Information Service. [cited 2018 Jun 29]. 1:1. [1 screen]. Available at: URL:http://kosis.kr/statisticsList/statisticsListIndex.do?menuId=M_01_01&vwcd=MT_ZTITLE&parmTabId=M_01_01#SelectStatsBoxDiv

2. Smith CH. New approaches to topical therapy. Clin Exp Deruratol. 2000; 25:567–74.
crossref pmid

3. Cho MS, Han CJ, Kim YH. The Use of Oriental Medicine for Pediatric Outpatients with Atopic Dermatitis. J Pediatr Korean Med. 2011; 25:2. 8–14.

4. Chen Y, Rennie D, Cormier Y, Dosman J. Association between Obesity and Atopy in Adults. Int Arch Allergy Immunol. 2010; 153:372–7.
crossref pmid

5. Boulet LP. Obesity and atopy. Clin Exp Allergy. 2015; 45:1. 75–86.
crossref pmid

6. WHO expert consultation. Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies. The Lancet. 2004; 363:9403. 157–63.
crossref pmid

7. Padwal RS, Majumdar SR. Drug treatments for obesity: orlistat, sibutramine, and rimonabant. The Lancet. 2007; 369:9555. 71–7.
crossref pmid

8. Kim YH. Overview for Pattern and Results of Herbal Medicine-derived Atopic Dermatitis Clinical Researches. J Korean Orient Pediatr. 2012; 26:2. 53–61.

9. Kim BA, Kim MS, Kang BM, Byeon SH, Park IH, Park JH, et al. Inhibitory Studies of Hwangryunhaedok-tang on Development of Atopic Dermatitis in NC/Nga Mice. Kor J Herbology. 2008; 23:2. 59–65.

10. Yamakawa J, Ishigaki Y, Takano F, Takahashi T, Yoshida J, Moriya J, et al. The Kampo medicines Orengedokuto, Bofutsushosan and Boiogito have different activities to regulate gene expressions in differentiated rat white adipocytes: comprehensive analysis of genetic profiles. Biol Pharm Bull. 2008; 31:11. 2083–9.
crossref pmid

11. Lee HL. Atopic Dermatitis. Korean J Pediatr. 2000; 43:9. 1161–7.

12. Cha KB, Kim YS, Seol IC. Literatual study on Atopic dermatitis. Journal of Haehwa Medicine. 2005; 14:2. 113–26.

13. Kang RY, Park BK, Gim SB, Choi HJ, Kim DH. The effects of HYT on various immunological factors related to pathogenesis of allergic dermatitis in NC/Nga mice induced by Biostir AD. Journal of Haehwa Medicine. 2009; 18:2. 47–62.

14. Park MC, Choi IH. The Efficacy of Sihocheonggan-san(Chaihuqinggan-san) Extract to Improve the Function of Stratum Corneum on Mice Model after Atopic Dermatitis Elicitation. J Korean Oriental Med. 2004; 25:3. 137–48.

15. Ki HP, Jang SI, Yun YG. Ameliorative Effects of Hwangnyeonhaedok-tang on Atopic Dermatitis. Herbal Formula Science. 2013; 21:1. 80–90.

16. Nagatani S, Guthikonda P, Thompson RC, Tsukamura H, Maeda KI, Foster DL. Evidence for GnRH regulation by leptin: leptin administration prevents reduced LH secretion during fasting. Neuroendocrinology. 1998; 67:370–6.
crossref pmid

17. Moon SJ, Kong JC, Kwon YD, Song YS, Han AR, Kwon YM, et al. Review of Clinical Studies on Oriental Medicine Treatment for Obesity in the Korean Literature. KOREAN JOURNAL OF ORIENTAL MEDICINE. 2010; 16:3. 85–93.

18. Ge H. Zhouhou Beiji Fang. Handbook of Prescriptions for Emergency. Taipei: People’s Health Publishing House;1996. p. 34–7.

19. Kim HK, Shin SW, Park JH. Inhibitory Effect of Galgeunhaegi-Tang on Compound 48/80 stimulated Allergic Reaction. JPPKM. 2009; 23: 2. 381–8.

20. Lim SC. Effects of Yullmoo (Coix lachryma-jobi var. mayuen stapf.) ext. on Lipidlowering and Serum Glucose in Hyperlipidemic Rat. Korean J Plant Res. 2006; 19:2. 126–9.

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