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JKM > Volume 39(1); 2018 > Article
Yang, Yun, Hong, Han, Kwon, Lee, Park, Kim, Choi, and Lee: Case Report on Long Term Survival of Glioblastoma Patient Treated with Integrative Medicine

Abstract

Objectives: This is a long-term survival case report about glioblastoma treated with western medicine and traditional Korean medicine. 28 year-old man diagnosed glioblastoma in 2003 went through 2 year’s chemotherapy first. After emergency brain surgery he took acupuncture and Korean herbal medication including Dohongsamul-tang and Boan-Manyeongdan in addition to conventional radiotherapy and chemotherapy for 3 years. Since May 2008, he was exclusively treated with traditional Korean medicine except taking antiplatelets only for 9 years. Though he has sequelae of tumor necrosis such as facial palsy and hemiparesis, he has survived without recurrence more than 14 years. We suggest that integrative approach including traditional Korean medicine can be a meaningful treatment option for malignant brain tumor. Further studies with more cases should be performed to establish proper treatment protocol of integrative medicine for brain tumor.

Fig 1
Brain MRI before and after the First Surgery (2005.05.19)
Lt: before (2005.05.15), Rt: after (2005.05.20)
jkm-39-1-75f1.gif
Fig. 2
Brain MRI Suspicious of Recurrence (2005. 11.17)
jkm-39-1-75f2.gif
Fig. 3
Brain MRI (2006. 06.27)
jkm-39-1-75f3.gif
Fig. 4
Brain MRI after the Second Surgery (2006.07.06)
jkm-39-1-75f4.gif
Fig. 5
Brain MRI Suspicious of Tumor Progression (2006.11.21)
jkm-39-1-75f5.gif
Fig. 6
Brain MRI (2009.01.08)
jkm-39-1-75f6.gif
Fig. 7
Brain MRI of Hemorrhage (2010.04.13)
jkm-39-1-75f7.gif
Fig. 8
Brain MRI (2015.06.11.)
jkm-39-1-75f8.gif
Table 1
Contents of treatment and results between 2005-05-30 and 2008-05-21.
Period 2005.05.30~2005.06.21 2005.06.21~2006.03.29 2006.03.30~2008.05.21
Western medicine Status post right temporal craniotomy & gross total resection of tumor with temporal lobectomy
Depakin, Medilac DS, Gliatilin, Ascorbic acid, Levopride
Radiotherapy 30 times (05.06.09~08.04) dendritic cell implantation 3 times (05.09.07~10.21)
Radioitherapy (05.12.08~12.21)
Temodal 4 times (05.11.17~06.02.23)
PCV (06.03.30)
Subtotal resection of tumor (06.07.05)
PCV (3 times), Temodal (6 times) (06.03.30.~07.02.12)
Embolectomy of left iliac vein (stent insertion), Warfarin sodium 5mg (06.08.30)
Nolvadex 10mg 1Tab twice/day -> 5Tab twice/day
Embolectomy of left iliac vein (07.07.14)
Clinically important events - Brain edema & compression of cerebral ventricle (05.12.08~12 21) Right facial paralysis and left side hemiparesis (06.05.02)
Progress in Facial paralysis and hemiparesis (06.06.27)
appetite hyperactivity, body weight gain (07.08.23)
Brain MRI - suspicion of recurrence at primary site (05.11.17. Fig. 2) Brain edema. No progression in brain tumor.
Necrosis of most tumor tissue (06.07.05 Fig. 4) tumor progressioin (07.11.21)
Herbal medication 半夏白朮天麻湯(for 3weeks) 桃紅四物湯加味方I
保安萬靈丹
小柴胡湯加味方
桃紅四物湯加味方II 加 人蔘
桃紅四物湯加味方II 加 人蔘, 鹿茸
右歸飮 加 人蔘, 鹿茸
Targets for herbal medicatioin Protection of normal brain tissue
Prevention of brain edema
Promotion of thrombus absorption
桃紅四物湯加味方I: prevention of tumor recurrence
保安萬靈丹: hemiparesis
小柴胡湯加味方: fever due to radiotherapy
桃紅四物湯加味方II 加 人蔘: tumor and general weakness
桃紅四物湯加味方II 加 鹿茸: bone marrow dysfunction
右歸飮 加 人蔘, 鹿茸: severer bone marrow dysfunction
Acupuncture 風池, 風府, 啞門, 曲池, 三陰交

PVC: Procarbazine, Lomustine (CCNU), Vincristine

Table 2
Contents of treatment and results between 2008-05-22 and 2017-08.
Period 2008.05.22~2010.04.12 2010.04.13
Herbal medication 桃紅四物湯加味方II
保安萬靈丹
桃紅四物湯加味方 II 加 牧丹皮, 三七根
Targets for herbal medication 桃紅四物湯加味方II: prevention of tumor recurrence
保安萬靈丹: prevention of tumor recurrence, alleviation of paralysis
Absorption of hemorrhage
Brain MRI Improvement in enhancing lesion (09.01.08. Fig. 6) Cerebral hemorrhage (10.04.13. Fig 7)
No specific findings (15.06.11. Fig 8)
Clinically important event Hiccup (10.04.13) aPTT=3.08, (11.07 19.) Warfarin sodium 5mg stop
aPTT=1.8, (11.07.22.) Warfarin sodium 2.5mg start
Acupuncture Acupuncture on the paralyzed region
to reduce spasticity and muscle stiffness, and to promote improvement by sensory stimulation

aPTT: activated partial thromboplastin time

참고문헌

1 Louis DN, Perry A, Reifenberger G, Deimling A, Figarella-Branger D, Cavenee WK, et al. The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary. Acta Neuropathol. 2016; 10.1007/s00401-016-1545-1
pmid

2 Nicholas S, Mathios D, Ruzevick J, Jackson C, Yang I, Lim M. Current Trends in Glioblastoma Multiforme Treatment: Radiation Therapy and Immune Checkpoint Inhibitors. Brain Tumor Res Treat. 2013; 1:2–8.
pmid pmc

3 Jung KW, Yoo H, Kong HJ, Won YJ, Park S, Lee SH. Population-based survival data for brain tumors in Korea. J neurooncol. 2012; 109:301–307.


4 Jeong JS, Park JW, Yoon SW. A Case of Metastatic Brain Tumor Patient with Nausea and Vomiting Treated with Gamibokryungbanha-tang. Korean J Orient Int Med. 2007; 28:4. 956–962.


5 Jeong UM, Kim HM, Jeong JS, Lee JS, Kim KS, Yoon SW. A Case Report of Regressed Metastatic Brain Tumors and Prolongation of Life with Allergen Removed Rhus verniciflua Stokes after Gamma Knife Radiosurgery. J Korean Med. 2009; 30:5. 157–162.


6 Kang Th, Won JH. Clinical Study on 1 Case of Patient with Astrocytoma. J Korea Oriental Oncology. 2000; 6:1. 181–188.


7 Wang Z, Chen S, Wang L. A Comprehensive Curative Effect of Malignant Brain Tumors Treated With VM26+MeCCNU and TCM. Cancer Prev Treat Res. 2000; 27:2. 152–153.


8 Zhou J, Liu H, Zhao M. Clinical research on Naoliu (Brain Tumor) powder in treating brain gliomas. Tianjin J Trad Chinese Med. 2008; 25:4. 277–280.


9 Fan Y, Hu Y, Li Y. Antifebrile Effect of Naoreqing oral Liquid on Post-operational Fever of Glioma or Meningioma Patients. Cninese J Int Med. 2001; 21:6. 406–408.
pmid

10 Zhang J. Analysis of Application of High Doses of Aconite Treatment of Typical Cases of Brain Tumor. Systems Med. 2016; 1:4. 60–63.


11 Sun W, Cui J, Zhu Y, Cao Y, Sun Y, Wang Z. Discussion and Analysis of Contemporary Famous Chinese Medicine Experts’ Clinical ExPeriences in Treating Brain Tumors. J Liaoning Univ TCM. 2014; 16:4. 59–60.


12 Guo C, Zhu G. Summary of the Features of Qian Bowen’s Thoughts on Clinical Treatment of Brain tumor. World Chinese Med. 2015; 10:10. 1552–1554.


13 Dolecek TA, Propp JM, Stroup NE, Kruchko C. CBTRUS statistical report:primary brain and central nervous tumors diagnosed in the United States in 2005–2009. Neuro Oncol. 2012; 14:suppl5. v1–v49.


14 Do YS, Jung KW, Ha J, Seo Y, Park CK, Won YJ, et al. An Updated Nationwide Epidemiology of Primary Brain Tumors in Republic of Korea, 2013. Brain Tumor Res Treat. 2017; 5:1. 16–23.


15 Omuro A, DeAngelis LM. Glioblastoma and Other Malignant Gliomas: A Clinical Review. JAMA. 2013; 310:17. 1842–1850.


16 Chung MJ, Park JY, Bang S, Park SW, Chung JB, Song SY. Phase II clinical trial to evaluate the efficacy and safety of activated T-lymphocyte cell therapy in gemcitabine refractory advanced pancreatic cancer. Pancreatology. 2013; 13:4. S45


17 Shin YS, Lee JA, Bae SH, Lee SY, Jang MK. Investigation into the Use of Complementary and Alternative Medicine and Factors Affecting Use in Korean Patients with Brain Tumors. J Korean Acad Fundam Nurs. 2013; 20:2. 147–156.


18 Lee JK, Song YK, Lim HH. Analgesic and anti-inflammatory effect of Scutellaria baicalensis. J Korean Med. 2007; 28:4. 124–135.


19 Lee HY, Kim JE, Kim M, Kim JH. A review of traditional Korean medical treatment for cancer-related cognitive impairment. J Korean Med. 2016; 37:3. 74–86.


20 Verlut C, Mouillet G, Magnin E, Buffet-Miny J, Viennet G, Cattin F, et al. Age, Neurological Status MRC scale, and Postoperative Morbidity are Prognostic Factors in Patients with Glioblastoma Treated by Chemoradiotherapy. Clinical Med Insight: Oncology. 2016; 1077–1082.


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