JKM > Volume 39(1); 2018 > Article
Yang, Yun, Hong, Han, Kwon, Lee, Park, Kim, Choi, and Lee: Case Report on Long Term Survival of Glioblastoma Patient Treated with Integrative Medicine


Objectives: This is a long-term survival case report about glioblastoma treated with western medicine and traditional Korean medicine. 28 year-old man diagnosed glioblastoma in 2003 went through 2 year’s chemotherapy first. After emergency brain surgery he took acupuncture and Korean herbal medication including Dohongsamul-tang and Boan-Manyeongdan in addition to conventional radiotherapy and chemotherapy for 3 years. Since May 2008, he was exclusively treated with traditional Korean medicine except taking antiplatelets only for 9 years. Though he has sequelae of tumor necrosis such as facial palsy and hemiparesis, he has survived without recurrence more than 14 years. We suggest that integrative approach including traditional Korean medicine can be a meaningful treatment option for malignant brain tumor. Further studies with more cases should be performed to establish proper treatment protocol of integrative medicine for brain tumor.

Fig 1
Brain MRI before and after the First Surgery (2005.05.19)
Lt: before (2005.05.15), Rt: after (2005.05.20)
Fig. 2
Brain MRI Suspicious of Recurrence (2005. 11.17)
Fig. 3
Brain MRI (2006. 06.27)
Fig. 4
Brain MRI after the Second Surgery (2006.07.06)
Fig. 5
Brain MRI Suspicious of Tumor Progression (2006.11.21)
Fig. 6
Brain MRI (2009.01.08)
Fig. 7
Brain MRI of Hemorrhage (2010.04.13)
Fig. 8
Brain MRI (2015.06.11.)
Table 1
Contents of treatment and results between 2005-05-30 and 2008-05-21.
Period 2005.05.30~2005.06.21 2005.06.21~2006.03.29 2006.03.30~2008.05.21
Western medicine Status post right temporal craniotomy & gross total resection of tumor with temporal lobectomy
Depakin, Medilac DS, Gliatilin, Ascorbic acid, Levopride
Radiotherapy 30 times (05.06.09~08.04) dendritic cell implantation 3 times (05.09.07~10.21)
Radioitherapy (05.12.08~12.21)
Temodal 4 times (05.11.17~06.02.23)
PCV (06.03.30)
Subtotal resection of tumor (06.07.05)
PCV (3 times), Temodal (6 times) (06.03.30.~07.02.12)
Embolectomy of left iliac vein (stent insertion), Warfarin sodium 5mg (06.08.30)
Nolvadex 10mg 1Tab twice/day -> 5Tab twice/day
Embolectomy of left iliac vein (07.07.14)
Clinically important events - Brain edema & compression of cerebral ventricle (05.12.08~12 21) Right facial paralysis and left side hemiparesis (06.05.02)
Progress in Facial paralysis and hemiparesis (06.06.27)
appetite hyperactivity, body weight gain (07.08.23)
Brain MRI - suspicion of recurrence at primary site (05.11.17. Fig. 2) Brain edema. No progression in brain tumor.
Necrosis of most tumor tissue (06.07.05 Fig. 4) tumor progressioin (07.11.21)
Herbal medication 半夏白朮天麻湯(for 3weeks) 桃紅四物湯加味方I
桃紅四物湯加味方II 加 人蔘
桃紅四物湯加味方II 加 人蔘, 鹿茸
右歸飮 加 人蔘, 鹿茸
Targets for herbal medicatioin Protection of normal brain tissue
Prevention of brain edema
Promotion of thrombus absorption
桃紅四物湯加味方I: prevention of tumor recurrence
保安萬靈丹: hemiparesis
小柴胡湯加味方: fever due to radiotherapy
桃紅四物湯加味方II 加 人蔘: tumor and general weakness
桃紅四物湯加味方II 加 鹿茸: bone marrow dysfunction
右歸飮 加 人蔘, 鹿茸: severer bone marrow dysfunction
Acupuncture 風池, 風府, 啞門, 曲池, 三陰交

PVC: Procarbazine, Lomustine (CCNU), Vincristine

Table 2
Contents of treatment and results between 2008-05-22 and 2017-08.
Period 2008.05.22~2010.04.12 2010.04.13
Herbal medication 桃紅四物湯加味方II
桃紅四物湯加味方 II 加 牧丹皮, 三七根
Targets for herbal medication 桃紅四物湯加味方II: prevention of tumor recurrence
保安萬靈丹: prevention of tumor recurrence, alleviation of paralysis
Absorption of hemorrhage
Brain MRI Improvement in enhancing lesion (09.01.08. Fig. 6) Cerebral hemorrhage (10.04.13. Fig 7)
No specific findings (15.06.11. Fig 8)
Clinically important event Hiccup (10.04.13) aPTT=3.08, (11.07 19.) Warfarin sodium 5mg stop
aPTT=1.8, (11.07.22.) Warfarin sodium 2.5mg start
Acupuncture Acupuncture on the paralyzed region
to reduce spasticity and muscle stiffness, and to promote improvement by sensory stimulation

aPTT: activated partial thromboplastin time


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