A Case Report on Two Psoriasis Patients with Insomnia

Ki Hoon Lee; Ji Eun Yang; Gyu Tae Chang; Lee, Ki Hoon; Yang, Ji Eun; Chang, Gyu Tae

doi:10.13048/jkm.15008

JKM > Volume 36(1); 2015 > Article

Lee, Yang, and Chang: A Case Report on Two Psoriasis Patients with Insomnia

Case Report

The Journal of Korean Oriental Medicine 2015; 36(1): 86-92.

DOI: https://doi.org/10.13048/jkm.15008

A Case Report on Two Psoriasis Patients with Insomnia

Ki Hoon Lee¹, Ji Eun Yang¹, Gyu Tae Chang²

¹Gangnam Dongyak Korean Medical Clinic, Kyung Hee University

²Department of Pediatrics. College of Korean Medicine, Kyung Hee University

Correspondence to : 장규태 (Gyu Tae Chang), 서울특별시 강동구 동남로 892 강동경희대학교 한방병원, Tel : +82-2-440-6231, E-mail : gtchang@khu.ac.kr

Received January 22, 2015 Revised March 16, 2015 Accepted March 17, 2015

Abstract

Objectives:

The purpose of this study is to present two treatment cases of psoriasis with insomnia.

Methods:

We administered Guibi-tang medication to the psoriasis patients with insomnia and tested the results by Psoriasis Area and Severity Index (PASI) and Insomnia Severity Index (ISI) as well.

Results:

After the treatment both the patients showed improvements in PASI and ISI as well. PASI of Patient 1 changed from 15.2 to 1.2 along with the change of ISI from 27 to 2. In case of Patient 2, PASI changed from 14.6 to 1.8 while ISI changed from 21 to 6.

Conclusions:

The results suggest that Guibi-tang can be an effective treatment for insomnia and psoriasis as well. Further studies will be needed to demonstrate conclusively the effect of Guibi-tang on psoriasis cure.

Keywords: psoriasis, insomnia, Guipi-tang, skin disease, PASI, ISI

Fig. 1.

before treatment (2013-11-11)

Fig. 2.

after 18 days (2013-11-29)

Fig. 3.

after 36 days (2013-12-17)

Fig. 4.

after 86 days (2014-03-04)

Fig. 5.

before treatment (2014-01-10)

Fig. 6.

after treatment (2014-02-15)

Table 1.

Variation of ISI Score

	Before Treatment	After 18 days	After 36 days	After 86 days
ISI Score	27	14	7	2

Table 2.

PASI Score of Case 1

	Before Treatment	After Treatment
Head	2×(3+3+3)×0.1=1.8	0×(0+0+0)×0.1=0
Trunk	2×(2+2+3)×0.3=4.2	1×(1+0+1)×0.3=0.6
Upper E.	2×(2+2+3)×0.2=2.8	1×(1+0+0)×0.2=0.2
Lower E.	2×(2+3+3)×0.4=6.4	1×(1+0+0)×0.4=0.4
PASI Score	15.2	1.2

Table 3.

Variation of ISI Score

	Before Treatment	After 25 days	After 36 days
ISI Score	21	14	6

Table 4.

PASI Score of Case 2

	Before Treatment	After Treatment
Head	3×(2+2+2)×0.1=1.8	0×(0+0+0)×0.1=0
Trunk	2×(2+2+2)×0.3=3.6	1×(1+0+1)×0.3=0.6
Upper E.	2×(2+3+2)×0.2=2.8	1×(1+0+1)×0.2=0.4
Lower E.	2×(2+3+3)×0.4=6.4	1×(1+0+1)×0.4=0.8
PASI Score	14.6	1.8

참고문헌

1.. Andrew Warin. Psoriasis. Seoul: Academia;2005. 7–8. p. 102

2.. Kim SC, Ahn KJ, Hann SK, Kim JW, Sung KJ, Kye YC, et al. Clinico-Epidemiologic study on the Abuse, Misuse, and Adverse Effects of Topical Dermatologic Drugs. Korean J Dermal. 2003; 41:9. 1129–35.

3.. Lee JH. Updates on Biologics in the Management of Psoriasis. Journal of the Korean Society for Psoriasis. 2009; 6:1. 11

4.. Park YH, Cheong SH, Lee JS, Kim SS, Shin HD. A Literatural Study of Psoriasis. The journal of K.O.M.S. 1989; 9:1. 131–6.

5.. Kim NK, Hwang CY, Lim GS. The Oriental and Occidental bibliographic Study of Psoriasis. The Journal of Oriental Medical Surgery Ophthalmology & Otolaryngology. 1999; 12:1. 171

6.. Hong SH. Reviewing Research on Korean medical treatment of Psoriasis. The Journal of Korean Medical Ophthalmology & Otolaryngology & Dermatology. 2013; 26:4. 26–42.

7.. Yang JI, Lee KH, Kim YS, Shin MK, Yoo JH, Chang GT. A Report on Liver Function Tests of 82 Psoriasis Patients Taking Herbal Medication over 3 Months viewing Research on Korean medical treatment of Psoriasis. The Journal of Korean Oriental Medicine. 2012; 33:3. 95–104.

8.. Camila H, Mariana R, Mariana SA, Sergio T, Monica LA. Sleep Loss and Cytokines Levels in an Experimental Model of Psoriasis. 2012. 0051183Available at: URL:http://journalss.plos.org/article?id=10.1371/journal.pone.0051183. Accessed Oct. 15, 2014

9.. Jang JS, Jung IC, Lee SR. The Literature Review on th Etiologic Theory of Insomnia. Journal of Oriental Medical Academy in Daejeon University. 2014; 13:1. 341–342.

10.. The Compilation committee. Oriental Pathology. Seoul: Haneuimonhwasa;2007. p. 394–396.

11.. Cheng GP. Yixuexinwu. Seoul: Seowondang;1994. p. 224

12.. Fredriksson T, Pettersson U. Severe psoriasis-oral therapy with a new retinoid. Dermatologica. 1978; 157:4. 238–44.

13.. Jacobs GD, Pace-Schott EF, Stickgold R, Otto MW. Cognitive behavior therapy and pharmacotherapy for insomnia. Arch InternMed. 2004; 164:1888–96.

14.. The Compilation committe. Dermatology. 4th ed.Seoul: Yeomungak;2002. p. 221–30.

15.. Kang WH. Atlas of Skin Disease. Seoul: Hanmibook;2003. p. 121

16.. Chao YF. Zhubingyuanhoulun. Seoul: Jungdam;1985. p. 461–2. p. 796–8.

17.. Park YG, Kim YK, Yun YG. A review on composition, action, compatibility of ingredients, clinical application of Gwibitang. The korean journal of oriental medical prescription. 2007; 15:2. 6

18.. Kim JH, Lee JK, Ha HK, Seo CS, Lee MY, Lee HY. Analysis of Studies on Guibi-tang (Guipitang) for Fundamental Establishment of Evidence Based Medicine (EBM). J of Oriental Neuropsychiatry. 2009; 20:3. 213

19.. Lee DJ, Kim SH. An Experimental Study on the Influence that the Medicinal Decoction of Kwi-Bi-Tang Affects Sleeping Hours and Sedation. K H Univ Med J. 1979; 2:1. 163–169.