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JKM > Volume 44(3); 2023 > Article
Lee, Kim, Park, and Jo: A Case of Prurigo Nodularis with Skin Rash that Occurred after COVID-19 Vaccination



This study is to report a case of prurigo nodularis with skin rash that occurred after COVID-19 vaccination improved by Korean medicine treatment.


The patient visited our hospital complaining of prurigo nodularis and skin rashes which occurred in various parts of the body (Total score 17). The patient complained of sleep disturbance (NRS 9) due to nighttime pruritus (NRS 7). Based on the patient’s symptoms, herbal medicine Soshiho-tang and acupuncture on the left Triple Energizer Hangyeok was prescribed.


Most of the skin symptoms improved significantly leaving only scars, minor scratches and pigmentation (Total score 17 → 6). The patient’s sleep condition improved (NRS 7 → 1) as the pruritus decreased from NRS 9 to 2.


This study is significant in that the patient with prurigo nodularis accompanied by skin rash effectively improved by the Korean Medicine treatment.

Fig. 1
Treatment timeline
Fig. 2
Clinical progress of purigo nodularis
Fig. 3
Clinical progress of skin rash
Table 1
Symptom Evaluation Index
Symptom Severity
Objective Symptoms Redness
Subjective Symptoms Pruritus
Sleep Loss
0 (None) ~ 10 (Severe)
Table 2
Prescription of Soshiho-tang
Name of Natural Medicine (Herbal Medicine) Weight(g)
柴胡 Bupleurum falcatum L. 8
半夏 Pinellia ternata (Thunb.) Makino 6
黃芩 Scutellaria baicalensis Georgi 3
人蔘 Panax ginseng C.A. Mey. 3
生薑 Zingiber officinale Roscoe 3
大棗 Ziziphus jujuba Mill. 4
甘草 Glycyrrhiza uralensis Fisch. 3

Total Amount 30
Table 3
Symptom Progress of Purigo Nodularis and Skin Rash
2022.02.28 2022.03.18 2022.04.05
Objective Symptoms Redness 3 1 1
Erythema 3 2 1
Papule 2 1 1
Nodule 3 2 1
Abrasion 3 2 1
Crusting 3 2 1

Subjective Symptoms Pruritus 9 5 2
Sleep Loss 7 3 1

Total 33 18 9


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