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JKM > Volume 39(4); 2018 > Article
ORIGINAL ARTICLE
J Korean Med. 2018;39(4): 16-29.         doi: https://doi.org/10.13048/jkm.18031
Hypothesis Proposal about Predictive Factors and Optimal Age for Response to Herbal Medicine Treatment for Height Gain in Children: a Retrospective Review
Jungtae Leem1,2,3  , Jeeyeun Kim4, Kyeungsuk Suh4, Youngkwern Lim4, and Junhee Lee3,5 
1Department of Internal Medicine of Korean Medicine, Dongshin Korean Medicine Hospital, 351, Omok-ro, Yangcheon-gu, Seoul, 07999, Republic of Korea
2Chung-Yeon Medical Institute, 64, Sangmujungang-ro, Seo-gu, Gwangju, 61949, Republic of Korea
3Korean Medicine Clinical Trial Center, Kyung Hee University Korean Medicine Hospital, 23 Kyungheedae-ro, Dongdaemun-gu, Seoul, 02447, South Korea
4Aijoafamily Korean Medical Clinic Network, 1587 Bongyeong-ro, Yeongtong-gu, Suwon-si Gyeonggi-do, 16703, South Korea
5Department of Sasang Constitutional Medicine, College of Korean Medicine, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul, 02447, South Korea
Corresponding Author: Youngkwern Lim ,Tel: +82-31-273-3375, Email: kinddoctor@hanmail.net
Corresponding Author: Junhee Lee ,Tel: +82-2-958-9280, Email: ssljh@khu.ac.kr
Received: February 6, 2018;  Revised: April 19, 2018.  Accepted: May 2, 2018.
ABSTRACT
Introduction: We aimed to investigate the predictive factors and optimal age for response to herbal medicine treatment for height gain in children.
Methods: This retrospective chart review included 61 children (age range, 5–16 years) treated for height gain between 2011 and 2015. A predictive model was established by multiple linear regression analysis. Dependent variables were defined by the differences in percentile before and after herbal medicine treatment. The optimal cutoff value of patient age was determined by receiver operating curve analysis.
Results: The age of initiation of herbal medicine therapy (p = 0.012) and administration of Forsythiae fructus (p = 0.002) were significant variables for treatment response. The adjusted R2 value was 0.231. The mean ages of the responder and non-responder groups were significantly different (p = 0.023). The optimal cutoff value of age for predicting treatment response was 9.75 years. Treatment response was better among children below 9.75 years of age.
Conclusions: Patient age and administration of Forsythiae fructus were identified as determinants of response to herbal medicine treatment. Treatment of rhinitis and initiation of height gain treatment at an early age are critical for better response. These findings will provide fundamental data for further research.
Keywords: Herbal medicine | Retrospective studies | Height gain | Height percentile | Children | Phytotherapy
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