Yang, Kim, Lee, Lee, Cho, Park, Ko, and Park: Effects of Korean Medicine on Postural Instability and Gait Difficulty in Patient with Parkinsonism: Retrospective Study

Abstract

Objectives

The purpose of this study was to investigate the effects of Korean Medicine on postural instability and gait difficulty(PIGD) in patient with parkinsonism.

Methods

We reviewed the charts of patients with parkinsonism who were admitted to the department of Korean internal medicine, stroke and neurological disorders center, Kyung Hee University Hospital at Gangdong from October 2009 to May 2017. We analyzed the data of UPDRS (Unified Parkinson’s disease rating scale) and calculated PIGD related UPDRS before and after the admission.

Results

The average of PIGD score for the 23 patients of Parkinsonism significantly decreased from 8.35 ± 5.13 to 4.52 ± 3.68 after treatment. The average of PIGD score for the 16 patients of idiopathic parkinson’s disease and 7 patients of atypical Parkinsonism decreased from 9.13 ± 4.46 to 4.63 ± 4.15 and from 6.57 ± 6.45 to 4.29 ± 2.56 after treatment, respectively.

Conclusions

These results provide that Korean Medicine has an effect on the motor function of patients who suffer from Parkinsonism with Postural Instability and Gait Difficulty. Furthermore it could be effective for improving activities of daily life.

Table 1
General Characteristics of Patients.
Characteristics Total (n=23) IPD* (n=16) Atypical Parkinsonism (n=7)
Mean of age (year) 66.43 ± 9.80 66.44 ± 11.06 66.43 ± 6.80
Sex (N) Man 3 0 3
Woman 20 16 4
Duration of disease (year) 4.39 ± 2.55 5.31 ± 2.44 2.29 ± 1.25
Duration of treatment (day) 19.70 ± 11.67 18.00 ± 9.81 23.57 ± 15.28
Subtype (N) MSA-P (5)
MSA-C (2)

Values are mean ± standard deviation or number

* IPD : Idiopathic Parkinson’s Disease

† MSA-P : Multiple System Atrophy-Parkinsonian subtype

‡ MSA-C : Multiple System Atrophy-Cerebellar dysfunction subtype

Table 2
Changes in Postural Instability and Gait Difficulty related Unified Parkinson’s Disease Rating Scale after Treatment in Parkinsonism Patients.
Before After p-value
Total PIGD* score 8.35 ± 5.13 4.52 ± 3.68 0.000
Falling 1.41 ± 1.30 0.61 ± 0.94 0.002
Freezing 1.44 ± 1.31 0.74 ± 0.92 0.005
Walking 1.80 ± 0.83 1.05 ± 0.49 0.001
Gait 1.50 ± 1.05 0.91 ± 0.61 0.002
Postural stability 1.70 ± 1.19 1.04 ± 0.93 0.001

Values are mean ± standard deviation

* PIGD : Postural Instability and Gait Difficulty

† p-value is calculated by paired t-test

‡ p-value is calculated by Wilcoxon signed rank test

Table 3
Changes in Postural Instability and Gait Difficulty related Unified Parkinson’s Disease Rating Scale after Treatment in Idiopathic Parkinson’s Disease Patients.
Before After p-value
Total PIGD* score 9.13 ± 4.46 4.63 ± 4.15 0.000
Falling 1.67 ± 1.18 0.63 ± 1.03 0.003
Freezing 1.63 ± 1.09 0.69 ± 1.01 0.002
Walking 2.00 ± 0.88 1.07 ± 0.46 0.006
Gait 1.73 ± 1.10 0.93 ± 0.70 0.004
Postural stability 1.75 ± 1.13 1.06 ± 1.00 0.004

Values are mean ± standard deviation

* PIGD : Postural Instability and Gait Difficulty

† p-value is calculated by paired t-test

‡ p-value is calculated by Wilcoxon signed rank test

Table 4
Changes in Postural Instability and Gait Difficulty related Unified Parkinson’s Disease Rating Scale after Treatment in Atypical Parkinsonism Patients.
Before After p-value
Total PIGD* score 6.57 ± 6.45 4.29 ± 2.56 0.224
Falling 0.86 ± 1.46 0.57 ± 0.79 0.457
Freezing 1.00 ± 1.73 0.86 ± 0.69 0.679
Walking 1.33 ± 0.52 1.00 ± 0.58 0.047
Gait 0.80 ± 0.45 0.86 ± 0.38 0.280
Postural stability 1.57 ± 1.40 1.00 ± 0.81 0.102

Values are mean ± standard deviation

* PIGD : Postural Instability and Gait Difficulty

† p-value is calculated by paired t-test

‡ p-value is calculated by Wilcoxon signed rank test

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