Delayed Neuropsychiatric Sequalae with Reversible Quadriplegia after Carbon Monoxide Intoxication: A Case Report

Article information

J Korean Med. 2018;39(3):73-80
Publication date (electronic) : 2018 September 30
doi : https://doi.org/10.13048/jkm.18026
Department of Circulatory Internal Medicine, College of Korean Medicine, Daejeon University
Correspondence to:김윤식(Yoon Sik Kim) 충남 천안시 서북구 노태산로 4 대전대부속천안한방병원 Tel: +82-41-521-7536, Fax: +82-41-521-7007, E-mail: yoonsik@dju.kr
Received 2018 July 27; Revised 2018 August 30; Accepted 2018 September 7.

Abstract

Carbon monoxide poisoning leads to hypoxia, which eventually leads to tissue ischemia. The delayed neuropsychiatric syndrome can arise in the period from 4 days to 5 weeks following carbon monoxide poisoning. This case report describes a male who suffered from delayed sequelae after self-inflicted carbon monoxide poisoning. At the time of admission, he had symptoms of quadriplegia, both upper limb ankylosis, gait disturbance, and dysuria. He was treated with acupuncture, electro-acupuncture, physical therapy, and Uwhangchungsim-won. Paraplegia improved considerably after 7 days in hospital, and paralysis of the both upper extremities improved after 14 days in hospital. He was able to walk holding on to his wheelchair after 28 days in hospital. He was hospitalized for 55 days and was discharged from the hospital in a fine condition for everyday life. This case report suggests the possibility that korean medicine for delayed neuropsychiatric syndrome.

Fig. 1

Brain MRI DWI of the date of the incident

Fig. 2

Brain MRI DWI 15 day after the incident

Fig. 3

Brain MRI T2 15 day after the incident

The Progress of The Patient

Korean version of Modified Barthel Index (K-MBI)

References

1. Prockop LD, Chichkova RI. Carbon monoxide intoxication: an updated review. J Neurol Sci 2007;262(1–2):122–30.
2. Lee JY, Song JH, Lim BS. Characteristics of suicide by carbon monoxide poisoning in Korea. J Korean official statistics 2016;21(1):57–83.
3. Weaver LK. Carbon monoxide poisoning. N Engl J Med 2009;360:1217–25.
4. Wolf SJ, Lavonas EJ, Sloan EP, Jagoda AS. Clinical Policy: Critical Issues in the Management of Adult Patients Presenting to the Emergency Department with Acute Carbon Monoxide Poisoning. Annals of Emergency Medicine 2008;51:138–152.
5. Kim W, Lee DH, Suh KY. A Clinical Study of Delayed Sequelae in Carbon Monoxide Intoxication. J Korean Neuropsychiatric Assoc 1987;26(4):675–88.
6. Lo Pardo D, Amedola D, Senatore G, Damiano A, Pezzuti G, Pugliese N, et al. Delayed neuropsychiatric syndrome after carbon monoxide poisoning: inclusion of hyperbaric oxygen therapy in the recovery protocol. Emergency Care Journal 2016;12(5675):28–30.
7. Kim DE, Kim KH, Kim JS, Shin GC, Lee WC. A Case of Delayed encephalopathy after Acute Carbon Monoxied Intoxication. J Korean Oriental Med 2001;22(3):169–178.
8. Park JY, Ko JC, Baek EG, Jun CY, Han YH, Ha KS. A Case of Delayed Postanoxic Encephalopathy after Carbon Monoxide Intoxication. J Int Korean Med 2002;:97–102.
9. Kim YY, Kim JY, Cho HY, Cho SH, Hwang WW. A Case Study of Patient with Delayed Post-Anoxicd Enchphalopathy Improved by Korean Traditional Treatment, Especially Jowiseung-chungtang. J of Oriental Neuropsychiatry 2008;19(3):205–17.
10. Roh SH, Park SH, Kim MS, Ok HJ, Kwon DI, Sun JJ. A Clinical Case Study of a Delayed Neuropsychic logical Sequelae Patient with Abnormal Brain Waves due to CO Intoxication. J Int Korean Med 2014;:233–239.
11. Zhang J, Piantadosi CA. Mitochondrial oxidative stress after carbon monoxide hypoxia in the rat brain. Journal of Clinical Investigation 1992;90( 4):1193–9.
12. Thom SR, Elbuken ME. Oxygen-dependent antagonism of lipid peroxidation. Free Radic Biol Med 1991;10(6):413–26.
13. Kim JH, Chang KH, Song IC, Kim KH, Kwon BJ, Kim HC, et al. Delayed encephalopathy of acute carbon monoxide intoxication: Diffusivity of cerebral white matter lesions. AJNR Am J Neuroradiol 2003;24(8):1592–7.
14. Choi IJ, Oh YH, Kim GT. Original Articles: Magnetic Resonance Imaging for the Prediction of Delayed Neuro-psychiatric Sequelae in Patients with Carbon Monoxide Poisoning DNS. J Korean Soc Emerg Med 2013;24(2):164–73.
15. Parkinson RB, Hopkins RO, Cleavinger HB, Weaver LK, Victoroff J, Foley JF, et al. White matter hyperintensities and neuropsychological outcome following carbon monoxide poisoning. Neurology 2002;58(10):1525–32.
16. Jian-Fang Z, Qiming G, Hua S, Bin L, Yuxiu D, Maofeng L, et al. A positive Babinski reflex predicts delayed neuropsychiatric sequelae in Chinese patients with carbon monoxide poisoning. Biomed Res Int Epub May. 15. 2014;
17. Beppu T. TThe role of MR imaging in assessment of brain damage from carbon monoxide poisoning: a review of the literature. AJNR Am J Neuroradiol 2014;Apr. 35(4):625–31.
18. Chang DC, Lee JT, Lo CP, Fan YM, Huang KL, Kang BH, et al. Hyperbaric oxygen ameliorates delayed neuropsychiatric syndrome of carbon monoxide poisoning. Undersea Hyperb Med 2010;Jan–Feb. 37(1):23–33.
19. Park HK, Joo SH, Choi JW, Park HS. A case of delayed encephalopathy of carbon monoxide intoxication. J Korean Neuropsychiatr Assoc 2013;52:463–467.
20. Lee SH, Shin KH, Kim JU. Effect of Seven Points of CVA Acupuncture on Cerebral Blood Flow. J Acupunct Res 2004;21(3):83–97.
21. Lee SW, Yun JM, Son JW, Kang BG, Park SM, Yun HJ, et al. The Effect of Electroacupuncture on Upper-Extremity Spasticity of Stroke Patients. J Int Korean Med 2007;28(3):492–501.
22. Yoo YD, Kim SY, Min SG. Effects of Electroacupuncture and Therapeutic Exercise on Skeletal Muscle in the Ischemic Stoke Rats. J Korean Society of Physical Therapy 2006;18( 3):9–21.
23. Heo J. (Remark by Jinjupyo). Donguibogam 2nd rev. edth ed. Seoul: Bubinbooks; 2009. p. 1026.
24. Kim LD, Yun SP, Lee SH, Kim EJ, Na BJ, Jung DW, et al. Effects of Uwhangchungsim-won (Niuhuangqingxin-yuan) on Systemic Blood Pressure, Pulse Rate, Cerebral Blood Flow, and Cerebrovascular Reactivity in Humans. J Int Korean Med 2004;25(3):440–50.

Article information Continued

Fig. 1

Brain MRI DWI of the date of the incident

Fig. 2

Brain MRI DWI 15 day after the incident

Fig. 3

Brain MRI T2 15 day after the incident

Table 1

The Progress of The Patient

Progress of the Patient
Adm. Upper limb motor weakness: Gr.3/1, Lower limb motor weakness: Gr.3/1, Finger mot(+/−), Toe mot(+/+)
8day Upper limb motor weakness: Gr.4/1, Lower limb motor weakness: Gr.4/4, Finger mot(+/+), Toe mot(+/+)
15day Upper limb motor weakness: Gr.4/3, Lower limb motor weakness: Gr.4/4
22day Upper limb motor weakness: Gr.4/3, Lower limb motor weakness: Gr.4/4,
The active ROM of the Lt. upper limb improved compared to before.
50day Upper limb motor weakness: Gr.4/4, Lower limb motor weakness: Gr.4/4,

Table 2

Korean version of Modified Barthel Index (K-MBI)

Category Adm. 8day 15day 22day 29day 36day 43day DisCharge
1, Personal hygiene 0 1 1 1 3 4 4 5
2. Bathing self 0 0 0 0 1 3 3 4
3. Feeding 0 5 5 5 8 8 10 10
4. Toilet 0 2 2 2 2 2 5 8
5. Stair climb 0 0 0 0 0 0 8 8
6. Dressing 0 0 0 2 2 5 8 10
7. Bowl control 0 5 5 5 5 8 10 10
8. Bladder control - 0 5 8 8 10 10 10
9. Ambulation 0 0 0 0 0 3 8 15
10. chair/bed transfer 0 0 0 0 1 8 12 15
Total score 0 13 18 23 30 51 78 95