A Clinical Research about Herbal Cosmetics Containing Caffeic acid phenethyl ester Isolated from Vespae Nidus on the Whitening Effects

Article information

J Korean Med. 2017;38(3):86-95

Publication date (electronic) : 2017 September 30

doi : https://doi.org/10.13048/jkm.17027

Ho-Yeol Cha ¹, Hee-Yeon Kim ¹^,², Ki-Tae Ha ², Jin-Hong Cheon ¹^,², Kibong Kim ¹^,²^,

¹Department of Pediatrics of Korean Medicine, Pusan National University Hospital

²School of Korean Medicine, Pusan National University

Correspondence to：김기봉(Kibong Kim) Department of Korean Pediatrics, Hospital of Korean Medicine, Pusan National University, Geumo-ro 20, Mulgeum-eup, Yangsan-si, Gyeongsangnam-do, 50612, Rep. of Korea. Tel：+82-55-360-5952, Fax：+82-55-360-5952, E-mail : kkb2630@gmail.com

Received 2017 August 16; Revised 2017 September 18; Accepted 2017 September 18.

Abstract

Objectives

The purpose of this clinical research was to investigate the effects of herbal cosmetics containing Caffeic acid phenethyl ester (CAPE), an ingredient compound of various herbs including Vespae Nidus, on the Whitening Effects.

Methods

A total of 20 subjects who visited Pusan National University Hospital from March 2nd, 2017 to April 11th, 2017 were included. In this study, we evaluated the visual evaluation, the melanin index (M) and erythema index (E) through skin analysis equipment, the subjective whitening improvement analysis, and the adverse reaction according to product use. Statistical analysis was performed with independent t-test and Mann-Whitney’s U test. Statistical significance was achieved if the probability was less than 5% (p<0.05)

Results

As a result of the visual evaluation, it was effective in improving skin whitening. The subjective whitening improvement analysis also showed positive results. However, no statistically significant differences were found between the test and control cosmetics in the melanin index (M) and erythema index (E) through skin analysis equipment. In the safety evaluation, some adverse reactions were reported, but no significant were observed directly from cosmetics.

Conclusions

Considering the above results, we have confirmed the possibility of herbal cosmetics containing containing CAPE of Vespae Nidus Extracts.

Keywords: Whitening; Herbal cosmetics; Caffeic acid phenethyl ester; Vespae Nidus; Propolis

Table 1

Clinical Studies on Leg Cramps

Table 2

Comparison Difference Form Baseline Between Groups

Table 3

Analysis Result of Subjective Whitening Improvement

Table 4

Analysis Result of Skin Adverse Reactions

References

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Article information Continued

Table 1

Clinical Studies on Leg Cramps

Variable	Observed value
	Control (n=20)					Experimental (n=20)					p value**
	mean	SD	median	IQR	p value*	mean	SD	median	IQR	p value*	p value**
육안평가
visit 2	3.800	±1.105	3.500	1.750	-	3.750	±1.070	3.500	1.000	-	0.5641	0.9083
visit 3	3.750	±1.118	4.000	1.750	0.6551	3.550	±0.945	3.000	1.000	0.1571	0.2061	0.5353
visit 4	3.350	±1.309	3.000	2.500	0.0031,#	2.850	±0.745	3.000	1.000	0.0011,#	0.0331,#	0.2313
멜라닌 지수 (기기평가)
visit 2	119.640	±21.902	114.200	27.350	-	119.775	±25.132	118.300	32.525	-	0.8521	0.8293
visit 3	131.850	±26.840	126.500	31.925	0.0011,#	134.010	±26.570	127.550	33.675	0.0012,#	0.6291	0.7663
visit 4	129.190	±24.325	124.750	26.225	0.0261,#	129.895	±27.448	124.200	36.150	0.0132,#	0.7532	0.9324
홍반 지수 (기기평가)
visit 2	321.685	±81.023	335.700	141.800	-	319.260	±74.481	320.750	80.800	-	0.7442	0.9224
visit 3	273.175	±55.931	280.500	89.575	0.0012,#	275.445	±57.821	279.500	83.150	0.0012,#	0.7642	0.9004
visit 4	276.380	±62.236	270.450	92.625	0.0012,#	277.645	±63.709	293.450	74.925	0.0042,#	0.7982	0.9504

P value<0.05

P values were compared within each group from baseline.

^**

P values were compared between groups.

P values were derived from Wilcoxon signed rank test.

P values were derived from paired t test.

P values were derived from Mann-Whitney’s U test.

⁴

P values were derived from independent t test.

(Shapiro-Wilk’s test was employed for test of normality assumption.)