A Case Report on Two Psoriasis Patients with Insomnia

Article information

J Korean Med. 2015;36(1):86-92
1Gangnam Dongyak Korean Medical Clinic, Kyung Hee University
2Department of Pediatrics. College of Korean Medicine, Kyung Hee University
Correspondence to : 장규태 (Gyu Tae Chang), 서울특별시 강동구 동남로 892 강동경희대학교 한방병원, Tel : +82-2-440-6231, E-mail : gtchang@khu.ac.kr
Received 2015 January 22; Revised 2015 March 16; Accepted 2015 March 17.

Abstract

Objectives:

The purpose of this study is to present two treatment cases of psoriasis with insomnia.

Methods:

We administered Guibi-tang medication to the psoriasis patients with insomnia and tested the results by Psoriasis Area and Severity Index (PASI) and Insomnia Severity Index (ISI) as well.

Results:

After the treatment both the patients showed improvements in PASI and ISI as well. PASI of Patient 1 changed from 15.2 to 1.2 along with the change of ISI from 27 to 2. In case of Patient 2, PASI changed from 14.6 to 1.8 while ISI changed from 21 to 6.

Conclusions:

The results suggest that Guibi-tang can be an effective treatment for insomnia and psoriasis as well. Further studies will be needed to demonstrate conclusively the effect of Guibi-tang on psoriasis cure.

Fig. 1.

before treatment (2013-11-11)

Fig. 2.

after 18 days (2013-11-29)

Fig. 3.

after 36 days (2013-12-17)

Fig. 4.

after 86 days (2014-03-04)

Fig. 5.

before treatment (2014-01-10)

Fig. 6.

after treatment (2014-02-15)

Variation of ISI Score

PASI Score of Case 1

Variation of ISI Score

PASI Score of Case 2

References

1. Andrew Warin. Psoriasis Seoul: Academia; 2005. (7–8)p. 102.
2. Kim SC, Ahn KJ, Hann SK, Kim JW, Sung KJ, Kye YC, et al. Clinico-Epidemiologic study on the Abuse, Misuse, and Adverse Effects of Topical Dermatologic Drugs. Korean J Dermal 2003;41(9):1129–35.
3. Lee JH. Updates on Biologics in the Management of Psoriasis. Journal of the Korean Society for Psoriasis 2009;6(1):11.
4. Park YH, Cheong SH, Lee JS, Kim SS, Shin HD. A Literatural Study of Psoriasis. The journal of K.O.M.S 1989;9(1):131–6.
5. Kim NK, Hwang CY, Lim GS. The Oriental and Occidental bibliographic Study of Psoriasis. The Journal of Oriental Medical Surgery Ophthalmology & Otolaryngology 1999;12(1):171.
6. Hong SH. Reviewing Research on Korean medical treatment of Psoriasis. The Journal of Korean Medical Ophthalmology & Otolaryngology & Dermatology 2013;26(4):26–42.
7. Yang JI, Lee KH, Kim YS, Shin MK, Yoo JH, Chang GT. A Report on Liver Function Tests of 82 Psoriasis Patients Taking Herbal Medication over 3 Months viewing Research on Korean medical treatment of Psoriasis. The Journal of Korean Oriental Medicine 2012;33(3):95–104.
8. Camila H, Mariana R, Mariana SA, Sergio T, Monica LA. Sleep Loss and Cytokines Levels in an Experimental Model of Psoriasis. 2012. 0051183. Available at: URL:http://journalss.plos.org/article?id=10.1371/journal.pone.0051183. Accessed Oct. 15, 2014.
9. Jang JS, Jung IC, Lee SR. The Literature Review on th Etiologic Theory of Insomnia. Journal of Oriental Medical Academy in Daejeon University 2014;13(1):341–342.
10. The Compilation committee. Oriental Pathology Seoul: Haneuimonhwasa; 2007. p. 394–396.
11. Cheng GP. Yixuexinwu Seoul: Seowondang; 1994. p. 224.
12. Fredriksson T, Pettersson U. Severe psoriasis-oral therapy with a new retinoid. Dermatologica 1978;157(4):238–44.
13. Jacobs GD, Pace-Schott EF, Stickgold R, Otto MW. Cognitive behavior therapy and pharmacotherapy for insomnia. Arch InternMed 2004;164:1888–96.
14. The Compilation committe. Dermatology 4th ed.th ed. Seoul: Yeomungak; 2002. p. 221–30.
15. Kang WH. Atlas of Skin Disease Seoul: Hanmibook; 2003. p. 121.
16. Chao YF. Zhubingyuanhoulun Seoul: Jungdam; 1985. p. 461–2. p. 796–8.
17. Park YG, Kim YK, Yun YG. A review on composition, action, compatibility of ingredients, clinical application of Gwibitang. The korean journal of oriental medical prescription 2007;15(2):6.
18. Kim JH, Lee JK, Ha HK, Seo CS, Lee MY, Lee HY. Analysis of Studies on Guibi-tang (Guipitang) for Fundamental Establishment of Evidence Based Medicine (EBM). J of Oriental Neuropsychiatry 2009;20(3):213.
19. Lee DJ, Kim SH. An Experimental Study on the Influence that the Medicinal Decoction of Kwi-Bi-Tang Affects Sleeping Hours and Sedation. K H Univ Med J 1979;2(1):163–169.

Article information Continued

Fig. 1.

before treatment (2013-11-11)

Fig. 2.

after 18 days (2013-11-29)

Fig. 3.

after 36 days (2013-12-17)

Fig. 4.

after 86 days (2014-03-04)

Fig. 5.

before treatment (2014-01-10)

Fig. 6.

after treatment (2014-02-15)

Table 1.

Variation of ISI Score

Before Treatment After 18 days After 36 days After 86 days
ISI Score 27 14 7 2

Table 2.

PASI Score of Case 1

Before Treatment After Treatment
Head 2×(3+3+3)×0.1=1.8 0×(0+0+0)×0.1=0
Trunk 2×(2+2+3)×0.3=4.2 1×(1+0+1)×0.3=0.6
Upper E. 2×(2+2+3)×0.2=2.8 1×(1+0+0)×0.2=0.2
Lower E. 2×(2+3+3)×0.4=6.4 1×(1+0+0)×0.4=0.4
PASI Score 15.2 1.2

Table 3.

Variation of ISI Score

Before Treatment After 25 days After 36 days
ISI Score 21 14 6

Table 4.

PASI Score of Case 2

Before Treatment After Treatment
Head 3×(2+2+2)×0.1=1.8 0×(0+0+0)×0.1=0
Trunk 2×(2+2+2)×0.3=3.6 1×(1+0+1)×0.3=0.6
Upper E. 2×(2+3+2)×0.2=2.8 1×(1+0+1)×0.2=0.4
Lower E. 2×(2+3+3)×0.4=6.4 1×(1+0+1)×0.4=0.8
PASI Score 14.6 1.8