| Puriton®의 급성 췌장염에 대한 보호 효과 |
김동욱1,2 
, 권빛나1,2
, 김광호7
, 배기상1,2,3
, 송경4,5,6
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1원광대학교 한의과대학 약리학교실
2원광대학교 한방심신증후군연구센터
3원광대학교 한국전통의학연구소
4원광대학교 약학대학 약학과
5원광대학교 약품연구소
6㈜퀀텀엔에스
7㈜카데시인코퍼레이션 |
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| Protective effects of Puriton® on acute pancreatitis |
| Dong-Uk Kim1,2
, Bitna Kweon1,2
, Kwang-Ho Kim7
, Gi-Sang Bae1,2,3
, and Kyung Song4,5,6
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1Department of Pharmacology, College of Korean Medicine, Wonkwang University
2Hanbang Cardio-Renal Syndrome Research Center, Wonkwang University
3Research center of Traditional Korean medicine, Wonkwang University
4Department of Pharmacy, College of Pharmacy, Wonkwang University
5Institute of Pharmaceutical Research and Development, Wonkwang University
6Quantum NS, Co., Ltd., Iksan, Jeollabuk-do, 54538, Republic of Korea
7Kadesh, Inc., Garden Grove, CA 92841, USA |
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| Corresponding Author:
Gi-Sang Bae ,Tel: +82-63-850-6842, Email: baegs888@wku.ac.kr |
| Corresponding Author:
Kyung Song ,Tel: +82-63-850-6817, Fax: +82-63-853-6821, Email: kyungsong@wku.ac.kr |
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Received: July 23, 2024; Revised: August 7, 2024. Accepted: August 19, 2024. |
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| ABSTRACT |
Objectives: Puriton® is the electrolyte enriched water consisting of 31 essential minerals from biotite, kaolinite, montmorillonite, serpentine, and clinochlore, and vermiculite. It has been reported to be bactericidal and virucidal. However, the protective effect of Puriton® against acute pancreatitis (AP) has not yet been studied. Therefore, we aimed to evaluate the protective effect of Puriton® against cerulein-induced AP.
Methods: AP was induced by intraperitoneal injections of cerulein (50 μg/kg) hourly for 6 times. Puriton® (100, 300, 500, or 700 μL) was administered orally 1 hour before the first cerulein injection. Mice were sacrificed 6 hours after the last cerulein injection. Pancreas, lung, and serum samples were quickly collected for further analysis.
Results: Administration of Puriton® did not reduce the ratio of pancreas weight to body weight. However, the increased serum amylase and lipase were decreased in the Puriton® administration group, and histological damage to pancreas and lung tissue was suppressed in the Puriton® 100 and 300 μL administration groups, but not in the Puriton® 500 and 700 μL administration groups. Additionally, among pro-inflammatory cytokines such as interleukin (IL)-1β, IL-6, and tumor necrosis factor (TNF)-α, the mRNA level of only IL-6 was decreased by Puriton® administration.
Conclusion: In summary, we showed that the administration of Puriton® improved the severity of cerulein-induced AP, suggesting the possibility of being an effective drug for AP. |
| Keywords:
Puriton® | Acute Pancreatitis (AP) | Cytokine |
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