Analysis of research trends on microneedle patches loaded pharmacopuncture preparation: A Literature Review

Minjeong Kim; Kim, Minjeong

doi:10.13048/jkm.24032

JKM > Volume 45(2); 2024 > Article

Kim: Analysis of research trends on microneedle patches loaded pharmacopuncture preparation: A Literature Review

Review Article

The Journal of Korean Medicine 2024; 45(2): 159-168.

Published online: June 01, 2024

DOI: https://doi.org/10.13048/jkm.24032

Analysis of research trends on microneedle patches loaded pharmacopuncture preparation: A Literature Review

Minjeong Kim

Department of Acupuncture & Moxibustion Medicine, College of Korean Medicine, Sangji University

Correspondence to: Minjeong Kim, Department of Acupuncture & Moxibustion Medicine, College of Korean Medicine, Sangji University, 83 Sangjidae-ro, Wonju, Gangwon-do, 26338, Republic of Korea, Tel: +82-33-741-9289, Fax: +82-33-741-9141, E-mail: goodykmj@hanmail.net

Received April 23, 2024 Revised May 9, 2024 Accepted May 9, 2024

Abstract

Objectives

The purpose of this study is to review the dissolving microneedle patches literature, which is loaded with pharmacopuncture preparation. By exploring types of pharmacopuncture preparation applied to microneedle patches, we aim to develop new potential preparation.

Methods

This review included both animal and human studies that published between February 2015 and March 2024. After searching, no RCTs were found, the final selected in-vivo and in-vitro studies were analyzed. A total of 13 articles were retrieved from the international database, and a total of 5 articles were retrieved from the domestic database. Finally, 7 studies were selected, and evaluated by the published year, country of publication, types of animal model, disease type, retention type, evaluation index, adverse effects.

Conclusions

According to 7 studies, pharmacopuncture preparation coated dissolving microneedle patch include bee venom, placenta, and ginseng in osteoarthritis, rheumatoid arthritis, hypertrophic scar, psoriasis, and neurodegeneration. In the future, follow-up studies on the safety, retention time, and optimal effective dose of the microneedle patches are expected.

Keywords: microneedle patch, dissolving microneedle patch, pharmacopuncture preparation, herbal agents loaded

ACKNOWLEDGMENTS

I thank graduate student Chang-Woo Sun for helping data extraction and organization.

Notes

INTEREST

The author has no conflicts of interest to declare.

ETHICAL STATEMENT

This research did not involve any human or animal experiment.

FUNDING

None.

Fig. 1

Flowchart of the study selection process according to PRISMA. PRISMA, Preferred Reporting Items for Systematic reviews and Meta-Analyses.

Table 1

Characteristics of the included in-vivo studies (6 articles)

Study	Animal Model	Disease Type	Preparation Type	Intervention Duration(day)	Evaluation Index	Adverse Effects
Huang C, et al. (2022) ²³⁾	Male ICR mice (6 weeks old; 20–25 g)	IMQ ointment-induced psoriasis	Rg3-Liposome	3 mins	psoriasis area and severity index (PASI score) Histological analysis	No comment
Du G, et al.(2021) ²⁴⁾	Rodent and murine AIA models Male BALB/c mice of 6–8 weeks old (body weight 18–20 g) Male Sprague Dawley (SD) rats of 6–8 weeks old (body weight 180–200 g)	rheumatoid arthritis	Melittin	every other day for 8 times(total 16)	body weight loss change of paw thickness clinical score of the symptoms histology of the paws	No comment
NGUYEN CD, et al.(2022) ²⁵⁾	Twenty-week-old BALB/c male (38–42 g/mouse) mice	scopolamine-induced neuro stress (neurodegenerative disorders)	bee venom(melittin)	2	Reactive oxygen species (ROS), lipid peroxidation (MDA), and adenosine triphosphate (ATP) levels Open field behavior test	No comment
NGUYEN CD, et al.(2022) ²⁵⁾	Twenty-week-old BALB/c male (38–42 g/mouse) mice		bee venom(melittin)	4	Morris water maze test	No comment
Cheng A, et al.(2024) ²⁶⁾	New Zealand white rabbits (aged 8–9 weeks)	hypertrophic scar	AS–ginsenoside Rb1–L–carnosine (A–G–C)	once a week for six weeks	thickness of the scar	No comment
Zheng L, et al.(2024) ²⁷⁾	Male Sprague-Dawley (SD) rats	rheumatoid arthritis	Melittin	once every 3 days for a total of 21 days	Swelling of rat paw degree of joint damage(X-ray) Serum cytokine	No comment
Zhao M, et al(2016) ²⁸⁾	Male Kunming mice (18e22 g) and Sprague Dawley rats	sodium urate induced acute gouty arthritis	Bee venom gel(BVG)	3mins	level of nitric oxide in serum	No comment
Zhao M, et al(2016) ²⁸⁾	Male Kunming mice (18e22 g) and Sprague Dawley rats	LPS-induced acute inflammation	Bee venom gel(BVG)	3mins	level of nitric oxide in serum	No comment

Table 2

Characteristics of the included in-vitro studies. (1 article)

Study	Cell Type	Disease Type	Preparation Type	Intervention Duration(hr)	Evaluation Index	Adverse Effects
Tansathien, K. et al.(2022) ²⁹⁾	human dermal fibroblasts (NHFs) human immortalized keratinocytes (HaCaTs))	exposed to UVB rays	placental extracts (GP, DP, or PP)	24	Skin Histology	Skin irritation (no pain, edema, severe redness)

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