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JKM > Volume 45(2); 2024 > Article
Kim: Analysis of research trends on microneedle patches loaded pharmacopuncture preparation: A Literature Review

Abstract

Objectives

The purpose of this study is to review the dissolving microneedle patches literature, which is loaded with pharmacopuncture preparation. By exploring types of pharmacopuncture preparation applied to microneedle patches, we aim to develop new potential preparation.

Methods

This review included both animal and human studies that published between February 2015 and March 2024. After searching, no RCTs were found, the final selected in-vivo and in-vitro studies were analyzed. A total of 13 articles were retrieved from the international database, and a total of 5 articles were retrieved from the domestic database. Finally, 7 studies were selected, and evaluated by the published year, country of publication, types of animal model, disease type, retention type, evaluation index, adverse effects.

Conclusions

According to 7 studies, pharmacopuncture preparation coated dissolving microneedle patch include bee venom, placenta, and ginseng in osteoarthritis, rheumatoid arthritis, hypertrophic scar, psoriasis, and neurodegeneration. In the future, follow-up studies on the safety, retention time, and optimal effective dose of the microneedle patches are expected.

ACKNOWLEDGMENTS

I thank graduate student Chang-Woo Sun for helping data extraction and organization.

Notes

INTEREST

The author has no conflicts of interest to declare.

ETHICAL STATEMENT

This research did not involve any human or animal experiment.

FUNDING

None.

Fig. 1
Flowchart of the study selection process according to PRISMA. PRISMA, Preferred Reporting Items for Systematic reviews and Meta-Analyses.
jkm-45-2-159f1.gif
Table 1
Characteristics of the included in-vivo studies (6 articles)
Study Animal Model Disease Type Preparation Type Intervention Duration(day) Evaluation Index Adverse Effects
Huang C, et al. (2022) 23) Male ICR mice (6 weeks old; 20–25 g) IMQ ointment-induced psoriasis Rg3-Liposome 3 mins
  1. psoriasis area and severity index (PASI score)

  2. Histological analysis

No comment
Du G, et al.(2021) 24) Rodent and murine AIA models
  1. Male BALB/c mice of 6–8 weeks old (body weight 18–20 g)

  2. Male Sprague Dawley (SD) rats of 6–8 weeks old (body weight 180–200 g)

rheumatoid arthritis Melittin every other day for 8 times(total 16)
  1. body weight loss

  2. change of paw thickness

  3. clinical score of the symptoms

  4. histology of the paws

No comment
NGUYEN CD, et al.(2022) 25) Twenty-week-old BALB/c male (38–42 g/mouse) mice scopolamine-induced neuro stress (neurodegenerative disorders) bee venom(melittin) 2
  1. Reactive oxygen species (ROS), lipid peroxidation (MDA), and adenosine triphosphate (ATP) levels

  2. Open field behavior test

No comment
4 Morris water maze test
Cheng A, et al.(2024) 26) New Zealand white rabbits (aged 8–9 weeks) hypertrophic scar AS–ginsenoside Rb1–L–carnosine (A–G–C) once a week for six weeks thickness of the scar No comment
Zheng L, et al.(2024) 27) Male Sprague-Dawley (SD) rats rheumatoid arthritis Melittin once every 3 days for a total of 21 days
  1. Swelling of rat paw

  2. degree of joint damage(X-ray)

  3. Serum cytokine

No comment
Zhao M, et al(2016) 28) Male Kunming mice (18e22 g) and Sprague Dawley rats sodium urate induced acute gouty arthritis Bee venom gel(BVG) 3mins level of nitric oxide in serum No comment
LPS-induced acute inflammation
Table 2
Characteristics of the included in-vitro studies. (1 article)
Study Cell Type Disease Type Preparation Type Intervention Duration(hr) Evaluation Index Adverse Effects
Tansathien, K. et al.(2022) 29)
  1. human dermal fibroblasts (NHFs)

  2. human immortalized keratinocytes (HaCaTs))

exposed to UVB rays placental extracts (GP, DP, or PP) 24 Skin Histology Skin irritation (no pain, edema, severe redness)

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