Home | Register | Login | Inquiries | Alerts | Sitemap |  


Advanced Search
JKM > Volume 41(1); 2020 > Article
Yang, Sung, Kim, and Lee: Effects of Long-Term Intake of Korean Medicine on Gynecology Patients’ Livers and Kidneys; Panel Study

Abstract

Objectives

To observe the effects on liver and kidney of gynecology patients’ during long term Korean Medicine.

Methods

This research was conducted as a panel study on 29 female gynecology patients at Korean medicine clinic and compares their conditions before, 3 months after, and 6 months after Intake of Korean medicine. This analysis was conducted to frequency(%), repeated measure ANOVA and significantly statistics was p<0.05, confidence interval.

Results

The most common conditions among the subjects were polycystic ovary syndrome, endometriosis, adenomyosis, and uterine myoma. Except in a few instances, liver functions (AST, ALT, γ-GTP) were within the normal range before and after the intake of Korean medicine. Further, while there was a slight change in liver functions when three months and six months after the intake, but there was no statistical significance (p>0.05). As for the kidney functions (BUN, Creatinine, BUN/Creatinine), they were within the normal range before and after the intake of Korean medicine. Further, while there was a slight change in kidney functions three months and six months after the intake, there was no statistical significance(p>0.05) either.

Conclusions

Based on these results, it can be concluded that Korean medicine does not have a negative impact on the gynecology patients’ liver and kidney.

Table 1
Sociodemography Characteristics (N=29)
Characteristics Frequency n(%)
Sex Male 0(0.0)
Female 29(100.0)

Age 10’s 3(10.3)
20’s 7(24.1)
30’s 8(27.6)
40’s 10(34.5)
50’s 1(3.4)

Body mass index <18.5 3(10.3)
18.5–22.9 16(55.2)
23.0–24.9 4(13.8)
25< 6(20.7)

Drinking No 22(75.9)
Yes 7(24.1)

Smoking No 29(100)
Yes 0(0)

Marital status Unmarried 16(55.2)
Married 13(44.8)

Occupation Profession 4(13.8)
Service, manufacturing workers 2(6.9)
Office workers 10(34.5)
House wife 9(31.0)
Student 4(13.8)

Gynecological diseases Cystic tumor 1(3.4)
Polycystic ovary syndrome 8(27.6)
Amenorrhea 1(3.4)
Cystitis 2(6.9)
Infertility 2(6.9)
Adenoma 4(13.8)
Uterine myoma 4(13.8)
Endometriosis 5(17.2)
Premature ovarian failure 1(3.4)
Vaginitis 1(3.4)
Table 2
Liver Function on Before, After 3, 6 Months Korean Medicine Intake (N=29)
LFT Normative Before intervention After 3 months After 6 months
AST Normal 26(89.7) 28(96.6) 26(89.7)
Abnormal 3(10.3) 1(3.4) 3(10.3)

ALT Normal 28(96.6) 27(93.1) 26(89.7)
Abnormal 1(3.4) 2(6.9) 3(10.3)

γ-GTP Normal 28(96.6) 27(93.1) 26(89.7)
Abnormal 1(3.4) 2(6.9) 3(10.3)

unit : n(%)

LFT= Liver function tests; AST=Aspartate transaminase; ALT= Alanine transaminase; γ-GTP=glutamyltransferase

Table 3
Kidney Function on Before, After 3, 6 Months Korean Medicine Intake (N=29)
RFT Normative Before intervention After 3 months After 6 months
BUN Normal 27(93.1) 25(86.2) 28(96.6)
Abnormal 2(6.9) 4(13.8) 1(3.4)

Creatinine Normal 28(96.6) 28(96.6) 29(100.0)
Abnormal 1(3.4) 1(3.4) 0(0)

BUN/Creatinine Normal 13(44.8) 16(55.2) 23(79.3)
Abnormal 16(55.2) 13(44.8) 6(20.7)

unit : n(%)

RFT=Renal function test; BUN=Blood urea nitrogen

Table 4
Comparison of liver Function on Before, After 3, 6 Months Korean Medicine Intake (N=29)
Liver Function Mean(SD) 95% confidence interval p-value
AST Before intervention 20.21(5.73) 18.02–22.39
After intervention 3 month 21.28(4.91) 19.41–23.14 1.00
6 month 23.07(10.54) 19.06–27.08 0.44

ALT Before intervention 14.76(6.71) 12.21–17.31
After intervention 3 month 13.93(5.56) 11.82–16.05 1.00
6 month 13.38(8.06) 10.31–16.45 0.48

γ-GTP Before intervention 17.46(21.55) 9.11–25.82
After intervention 3 month 15.36(16.01) 9.15–21.57 0.51
6 month 15.04(12.73) 10.10–19.98 0.78

unit : IU/L

Table 5
Comparison of Kidney Function on Before, After 3, 6 Months Korean Medicine Intake
Kidney Function Mean(SD) 95% confidence interval p-value
BUN Before intervention 11.58(3.99) 10.04–13.13
After intervention 3 month 10.94(3.75) 9.48–12.39 1.00
6 month 11.11(3.18) 9.88–12.34 1.00

Creatinine Before intervention 0.64(0.12) 0.59–0.68
After intervention 3 month 0.65(0.11) 0.59–0.68 1.00
6 month 0.66(0.09) 0.62–0.70 1.00

BUN/Creatinine Before intervention 18.46(6.09) 16.14–20.77
After intervention 3 month 17.10(7.04) 14.50–19.71 1.00
6 month 16.44(4.10) 14.88–18.00 0.94

unit; mg/dL

참고문헌

1. Lee SD, Park YC. Toxicology for Herbal Medicine I. Seoul: Koreanstudies Information;2012. p. 45


2. Jung IK, Kim JS, Lee HS, Ryu SH, Kwak DI. The Survey of the Concept about Using Herb-Medication & the Effect on Treatment -Seeking Behavior in Psychiatric and Non-Psychiatric Patients. J Korean Neuropsychiatr Assoc. 2001; 40:6. 1031–43.


3. Kim DJ. A preliminary multicenter study for the detection of toxic hepatitis induced by various plant preparations and healthy foods and the development of nationwide reporting system of toxic hepatitis. Korea Food & Drug Administration;2003.


4. Jang IS. A Review on the Report about Drug-induced Hepatitis published by the National Institute of Toxicological Research. J Korean Oriental Med. 2004; 25:3. 78–89.


5. Cho BS. Kidney Disease and Herbal Medicine. Kidney and health. 2005; 8:0. 8–10.


6. Kim SY. Efficacy versus Effectiveness. Korean J Fam Med. 2013; 34:4. 227
crossref pmid pmc

7. Kim DI. Korean Medicine Clinical Care Guidelines for Infertility. 2010; 54–73.


8. Jang HJ, Yoon YK, Sun TC, Song WS, Kwon SK. A Study Of Effects on Renal Function from Continuous Long-Term Herbal Medication. Korean J Intern Med. 2004; 25:4. 300–5.


9. Kang MH, Sul MC, Moon JY, Lee SH. The clinical study of LFT levels in 117 out-patients while taking herbal medicine for 6 months. Korean J Orient Int Med. 2007; 28:fal. 107–12.


10. Lee BC, Choi EJ. The Safety and Efficacy of Herbal Medicine for 107 Psoriasis Patients: A Retrospective Chart Review. J Korean Med. 2016; 37:1. 34–40.
crossref

11. Lee J, Shin JS, Kim MR, Byun JH, Lee SY, Shin YS, et al. Liver enzyme abnormalities intaking traditional herbal medicine in Korea : A retro spective large sample cohort study of musculoskeletal disorder patients. J Ethnopharmacol. 2015; 169:407–12.
crossref pmid

12. Cho JH, Oh DS, Hong SH, Ko H, Lee NH, Park SE, et al. A nationwide study of the incidence rate of herb–induced liver injury in Korea. Arch Toxicol. 2017; 91:12. 4009–15.
crossref pmid pmc

13. Samkwang Medical Laboratories. 2018 Comprehensive Inspection Brochure. Seoul: Samkwang Medical Laboratories;2018. p. 237–40.


14. Hosten AO. BUN and Creatinine. Walker HK, Hall WD, Hurst JW, editors. Clinical Methods: The History, Physical, and Laboratory Examinations. 3rd edition. Boston: Butterworths;1990. p. 874–8.


15. Park JK, Jang SJ. Health Statistics with SPSS/PC +. Seoul: Woohyun;1993.


16. Byun SH, Seo BI. A study on medicinal theory of Wang-Ang. Herbal Formula Science. 1999; 7:1. 77–87.


17. Kim HU, Ryu JY, Lee JO, Lee SY. A systems approach to traditional oriental medicine. Nat Biotechnol. 2015; 33. 264–8.
crossref pmid

18. Park YC, Park HM, Lee SD. Inducible Mechanisms for Hepatotoxicity caused by Traditional Korean Medicines in a View of Toxicology. J Korean Oriental Med. 2011; 32:4. 48–67.


19. Kim DW, Oh SH, Lee EJ, Kim HK, An IH, et al. The Change of Renal Function in Diabetic Nephropathy and Chronic Renal Failure Patients with Long Term Herb Medication by Frequently Prescribed Formular. J Korean Oriental Med. 2004; 18:4. 1207–12.


20. Lee SD, Park YC. Toxicology for Herbal Medicine II. Seoul: Koreanstudies Information;2013. p. 227–230.


21. Lim JH, Kim YS, Lee YN, Kim SK, Jung SK, Jang JY, et al. Clinical Characteristics and Pathological Findings in Patients with Toxic Hepatitis. Korean J Medicine. 2011; 81:1. 55–63.


22. Kang SH, Kim JI, Jeong KH, Ko KH, Ko PG, Hwang SW, et al. Clinical characteristics of 159 cases of acute toxic hepatitis. Korean J Hepatol. 2008; 14:4. 483–92.
crossref pmid

23. Lee WY, Park BC, Kim HS, Joung KO, Yoon SI, Kwon SK, et al. A case of acute interstitial nephropathy and toxic hepatitis after short-term herbal medication. Korean J Med. 2007; 103–106.


24. Lee HU, Baek HK, Baek KM, Kim JH, Kim JW, Shim JC, et al. Comparison of Liver Function and Kidney Function Test Score by Administration Period of Herbal Medication. J Int Korean Med. 2006; 27:110.


25. Korean Medicine Encyclopedia [Internet]. Endometriosis. 2018. MAR. 22. [cited 2020 JAN 16]. Available from:URL: https://www.kmpedia.kr/contents/contents/contents_popup_full/content_id/137


26. Lee EY, Jung SH, Moon ES. A Study on Consumer Awareness and Intention to Take Herbal Medicine. In : Korean Society of Home Management Conference; 2007. p. 136–46.


27. Uchino S, Bellomo R, Goldsmith D. The meaning of the blood urea nitrogen/Creatinine ratio in acute kidney injury. Clin Kidney J. 2012; 5:187–91.
crossref pmid pmc

28. Kasper D, et al. Harrison’s Principles of Internal Medicine. 16th. Seoul: McGraw-Hill;2006. p. 1976–80.


TOOLS
PDF Links  PDF Links
Full text via DOI  Full text via DOI
PubReader  PubReader
Download Citation  Download Citation
  E-Mail
  Print
Share:      
METRICS
1
Crossref
1,625
View
59
Download
Editorial office contact information
3F, #26-27 Gayang-dong, Gangseo-gu Seoul, 157-200 Seoul, Korea
The Society of Korean Medicine
Tel : +82-2-2658-3627   Fax : +82-2-2658-3631   E-mail : skom1953@daum.net
About |  Browse Articles |  Current Issue |  For Authors and Reviewers
Developed in M2PI