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JKM > Volume 39(4); 2018 > Article
ORIGINAL ARTICLE
J Korean Med. 2018;39(4): 126-135.         doi: https://doi.org/10.13048/jkm.18040
Effects of GHX02 on Chronic Obstructive Pulmonary Disease Mouse Model
Won-Kyung Yang1,2  , Yee Ran Lyu2  , Seung-Hyung Kim1  , and Yang Chun Park1,2 
1Institute of Traditional Medicine and Bioscience, Daejeon University, Daejeon, Korea
2Division of Respiratory System, Dep. of Internal Medicine, College of Korean Medicine, Daejeon University, Daejeon, Korea
Corresponding Author: Yang Chun Park ,Tel: 82-42-470-9126, Fax: 82-42-470-9486, Email: omdpyc@dju.kr
Received: November 29, 2018;  Revised: December 14, 2018.  Accepted: December 14, 2018.
ABSTRACT
Objectives: Chronic obstructive pulmonary disease (COPD) is characterized by chronic inflammation and irreversible airflow. This study aimed to evaluate the effects of GHX02 in a COPD-induced mouse model.
Methods: The COPD mouse model was established by exposure to cigarette smoke extract and lipopolysaccharide which were administered by intratracheal injection three times with a 7 day interval. GHX02 (100, 200, 400 mg/kg) and all other drugs were orally administrated for 14 days from Day 7 to Day 21.
Results: GHX02 significantly decreased the neutrophil counts in bronchoalveolar lavage fluid (BALF) and the number of CD4+, CD8+, CD69+, and CD11b+/GR1+ cells in BALF and lung cells. GHX02 also suppressed the secretion of tumor necrosis factor-alpha (TNF-α), interleukin-17A, macrophage inflammatory protein 2 (MIP2), and chemokine (C–X–C motif) ligand 1 (CXCL-1) in BALF and ameliorated the lung pathological changes.
Conclusions: Thus, GHX02 effectively inhibited airway inflammation by inhibiting migration of inflammatory cells and expression of pro-inflammatory cytokines. Therefore, GHX02 may be a promising therapeutic agent for COPD.
Keywords: chronic obstructive pulmonary disease | cigarette smoke | airway inflammation | herbal medicine | GHX02
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