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JKM > Volume 39(4); 2018 > Article
J Korean Med. 2018;39(4): 1-15.         doi: https://doi.org/10.13048/jkm.18030
Effect of acupuncture on short-term memory and apoptosis after transient cerebral ischemia in gerbils
In-Ho Choi, and Hyung-Ho Lim
Colledge of Korean Medicine, Gachon University
Corresponding Author: Hyung-Ho Lim ,Tel: +82-31-750-8599, Fax: +82-31-750-5416, Email: omdlimhh@gachon.ac.kr
Received: October 29, 2018;  Revised: November 7, 2018.  Accepted: November 7, 2018.
Objectives: Cerebral ischemia results from a variety of causes that cerebral blood flow is reduced due to a transient or permanent occlusion of cerebral arteries. Reactive astrocytes and microglial activation plays an important role in the neuronal cell death during ischemic insult. Acupunctural treatment is effective for symptom improvement in cerebrovascular accident, including cerebral ischemia.
Methods: In the present study, the effects of acupuncture at the ST40 acupoint on short-term memory and apoptosis in the hippocampal CA1 region following transient global cerebral ischemia were investigated using gerbils. Transient global ischemia was induced by occlusion of both common carotid arteries with aneurysm clips for 5 min. Acupuncture stimulation was conducted once daily for 7 consecutive days, starting one day after surgery.
Results: In the present results, ischemia induction deteriorated short term memory, increased apoptosis, and induced reactive astrocyte and microglial activation. Acupuncture at ST40 acupoint ameliorated ischemia-induced short-term memory impairment by suppressing apoptosis in the hippocampus through down-regulation of reactive astrocytes and microglial activation.
Conclusion: The present study suggests that acupuncture at the ST40 acupoint can be used for treatment of patients with cerebral stroke.
Keywords: Acupuncture | Fenglong acupoint (ST40) | Ischemia | Short-term memory | Apoptosis | Reactive astrocytes | Microglial activation
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