The Effect of Geopungchunghyul-dan on Circumferential Strain of Carotid Artery: A Case Series

Sang-Kwan Moon; Minho Jung; Seungwon Kwon; Seung-Yeon Cho; Seong-Uk Park; Woo-Sang Jung; Jung-Mi Park; Chang-Nam Ko; Ki-Ho Cho; Moon, Sang-Kwan; Jung, Minho; Kwon, Seungwon; Cho, Seung-Yeon; Park, Seong-Uk; Jung, Woo-Sang; Park, Jung-Mi; Ko, Chang-Nam; Cho, Ki-Ho

doi:10.13048/jkm.18009

JKM > Volume 39(1); 2018 > Article

Moon, Jung, Kwon, Cho, Park, Jung, Park, Ko, and Cho: The Effect of Geopungchunghyul-dan on Circumferential Strain of Carotid Artery: A Case Series

Case Report

The Journal of Korean Medicine 2018; 39(1): 86-94.

Published online: March 31, 2018

DOI: https://doi.org/10.13048/jkm.18009

The Effect of Geopungchunghyul-dan on Circumferential Strain of Carotid Artery: A Case Series

Sang-Kwan Moon¹^{, 2}, Minho Jung¹, Seungwon Kwon¹^{, 2}, Seung-Yeon Cho¹^{, 2}, Seong-Uk Park¹^{, 2}, Woo-Sang Jung¹^{, 2}, Jung-Mi Park¹^{, 2}, Chang-Nam Ko¹^{, 2}, Ki-Ho Cho¹^{, 2}

¹Department of Cardiology and Neurology, Kyung Hee University Korean Medicine Hospital

²Department of Cardiology and Neurology, College of Korean Medicine, Kyung Hee University

Correspondence to: 정민호 (Minho Jung), 경희대학교 한의과대학 순환신경내과학 교실, Tel: +82-2-958-9129, Fax: +82-2-958-9104, E-mail: tox37@naver.com

Received November 30, 2017 Revised March 5, 2018 Accepted March 2, 2018

Abstract

Objectives

This study is aimed to examine the effect of Geopungchunghyul-dan on circumferential strain of carotid artery in outpatients of Kyung Hee University hospital of Korean Medicine.

Methods

Retrospective chart review is used from June 2016 to August 2017 for outpatients of Kyung Hee University hospital of Korean Medicine. 14 patients taking Geopungchunghyul-dan over 1 month were speculated. Data of circumferential strain and intima-media thickness was taken from carotid ultrasonography and processed by Wilcoxon signed-rank test.

Results

Geopungchunghyul-dan lowered circumferential strain of both carotid arteries after 1 month of administration (p<0.05). Intima-media thickness of both carotid arteries did not changed significantly.

Conclusions

Geopungchunghyul-dan may ameliorate arterial stiffness.

Keywords: Geopungchunghyul-dan, Circumferential strain, Arterial stiffness

Fig. 1

Change of left circumferential strain for 1 month of treatment.

Fig. 2

Change of right circumferential strain for 1 month of treatment.

Fig. 3

Change of left circumferential strain for 2 months of treatment

Fig. 4

Change of right circumferential strain for 2 months of treatment

Fig. 5

Change of both circumferential strain for 3 months of treatment

Table 1

Clinical Characteristics of Patients. (n=14)

		Number of patients (%)
Main impression	Small vessel disease	5 (35.71)
	Tension type headache	2 (14.29)
	Transient ischemic attack	2 (14.29)
	Vestibular neuritis	2 (14.29)
	Cervicalgia	1 (7.14)
	Vasovagal syncope	1 (7.14)
	Facial myokymia	1 (7.14)

Chief complain	Headache	4 (28.57)
	Dysarthria	4 (28.57)
	One side weakness	3 (21.43)
	Facial palsy	3 (21.43)
	Dizziness	3 (21.43)
	General weakness	3 (21.43)
	One side numbness	2 (14.29)
	Motor aphasia	1 (7.14)
	Aphthous ulcer	1 (7.14)
	Tinnitus	1 (7.14)
	Facial myokymia	1 (7.14)

CVD risk factor	Hypertension	11 (78.57)
	Diabetes mellitus	9 (64.29)
	Dyslipidemia	8 (57.14)
Social history	Smoke	2 (14.29)
Social history	Alcohol	4 (28.57)

Table 2

Mean Value and Standard Deviation of Circumferential Strain and Intima-Media Thickness of each Common Carotid Artery at Start(Baseline) and 1 Month of Treatment.

	Baseline	1 month	p value
CS (Left)	1.76±0.75	2.09±0.81	0.003*
CS (Right)	1.80±0.56	2.16±0.75	0.013*
IMT (Left)	0.76±0.10	0.79±0.11	0.054
IMT (Right)	0.79±0.11	0.80±0.10	0.726

CS, circumferential strain; IMT, intima-media thickness.

Wilcoxon signed-rank tests were used for comparison between start and 1 month of treatment.

* Statistically significant at p<0.05

Table 3

Rate of Change in Circumferential Strain for 1 Month of Treatment

Patient	Rate of change in CS (%)

	Left	Right
#1	22.97	−5.81
#2	63.64	45.26
#3	1.44	4.76
#4	6.27	21.26
#5	20.23	6.54
#6	13.13	39.7
#7	22.08	39.87
#8	34.1	3.4
#9	−2.8	6.99
#10	6.62	23.68
#11	28.21	34.45
#12	72.46	100
#13	−6.8	−25.19
#14	44.12	6.57

mean	23.26	21.53
SD	22.94	28.98

CS, circumferential strain; SD, standard deviation

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