The Effect of Drinking Alcohol on Bio-electrical Potential at Twelve Source Points : A Cross-over Study

Jung-Wan Kim; Jae-Hong Kim; Yun-Kyoung Yim; Kim, Jung-Wan; Kim, Jae-Hong; Yim, Yun-Kyoung

doi:10.13048/jkm.18005

JKM > Volume 39(1); 2018 > Article

Kim, Kim, and Yim: The Effect of Drinking Alcohol on Bio-electrical Potential at Twelve Source Points: A Cross-over Study

Original Article

The Journal of Korean Medicine 2018; 39(1): 44-54.

Published online: March 31, 2018

DOI: https://doi.org/10.13048/jkm.18005

The Effect of Drinking Alcohol on Bio-electrical Potential at Twelve Source Points: A Cross-over Study

Jung-Wan Kim¹

, Jae-Hong Kim¹

, Yun-Kyoung Yim¹^{, *}

¹Department of Meridian & Acupoints, College of Korean Medicine, Daejeon University

Correspondence to: 임윤경 (Yun-Kyoung Yim), Department of Meridian and Acupoints, College of Korean Medicine, Daejeon University 62, Daehak-ro, Dong-gu, Daejeon, 34520, Republic of Korea. Tel: +82-42-280-2610, Fax: +82-42-280-2641 E-mail: docwindy@dju.kr

Received February 23, 2018 Revised March 15, 2018 Accepted March 15, 2018

Abstract

Objectives

The objective of this study is to investigate the effects of drinking alcohol on bio-electrical potential at twelve source points.

Methods

Twenty healthy adults were assigned to alcohol and water groups by a random cross-over design. Bio-electrical potential at twelve source points were measured before and after drinking alcohol or water and the change of bio-electrical potential was analyzed and compared between the alcohol and the water groups.

Results

Bio-electrical potential at LI4, ST42, KI3, PC7, TE4, GB40, LR3 in the alcohol group was significantly increased compared to those in the water group.

Conclusions

Drinking alcohol increased bio-electrical potential at source points of LI, ST, KI, PC, TE, GB and LR in healthy human subjects.

Keywords: Bio-electrical potential, Source points, Drinking, Alcohol

Fig. 1

Experimental protocol

Fig. 2

Change of Blood Alcohol Concentration (BAC)

Fig. 3

Effects of Alcohol on Bio-electrical potential at Twelve Source Points

Bio-electrical potential was detected at twelve source points before and after drinking alcohol or water. The detected signal was amplified and saved in the connected computer. The changes of bio-electrical potential at each time point was calculated and compared between the alcohol group and the water group. The scales on the y-axes are digital values converted with 16-bit resolution. Data were expressed as mean (n=20).

Red full circle: Alcohol group

Blue empty circle: Water group

* P < 0.05 vs Water group

Table 1

General Characteristics of Subjects

	Mean ± SD
Age(year)	22.67 ± 2.24
Height(cm)	171.14 ± 6.62
Weight(kg)	68.66 ± 12.69
BMI(kg/m²)	23.33 ± 3.52
Body Temperature(°C)	36.08 ± 0.51
Systolic Blood Pressure(mmHg)	123.49 ± 14.07
Diastolic Blood Pressure(mmHg)	78.13 ± 11.52
Time after urination(h)	0.57 ± 1.01

Table 2

Comparison of Bio-electrical Potential Change between the Alcohol Group and the Water group at Twelve Source Points

Source Point	P value (Alcohol vs Water)
LU9	0.126
LI4	0.005^*
ST42	0.005^*
SP3	0.129
HT7	0.070
SI4	0.129
BL64	0.134
KI3	0.011^*
PC7	0.013^*
TE4	0.013^*
GB40	0.010^*
LR3	0.023^*

참고문헌

1. Ministry of Health and Welfare. Blue Bird Plan 2010. Sejong. Ministry of Health and Welfare;(2006). p. 11

2. Park, SS. Study on the Compulsory Treatment in the Crime of Problem Drinking. Journal of Korean Public Police and Security Studies, (2011). 7(4), 223-46.

3. Ministry of Health and Welfare. Korea National Health & Nutrition Examination Survey 2015. Osong. Centers for Disease Control & Prevention;(2015). p. 215

4. Lee SM, Yoon YD, Hyun GR, Lee EM. Monetary Sanctions of Health Hazard Factor for secure Health Care finances. Seoul. National Health Insurance Service;(2012). p. 20

5. Ikeda, K, Saitoh, S, & Suzuki, Y, et al. Disease progression and hepatocellular carcinogenesis in patients with chronic viral hepatitis: a prospective observation of 2215 patients. J Hepatol, (1998). 28, 930-8.

6. Hong, YC, Park, JI, Lee, WC, & Lee, KS. Case-Control Study on Effects of Alcohol Intake and Smoking to Gastritis of Korean Adult Men. Journal of Preventive Medicine and Public Health, (1992). 25(3), 238-46.

7. Kin, JS. The Effect of Alcohol on the Small Intestine and Large Intestine. Health Living, (2007). 56, 28-9.

8. Ha, JY. Drinking Problems, Stress, Depression and Self-esteem of University Students. J Korean Acad Adult Nurs, (2010). 22(2), 182-9.

9. Do, EY, & Do, BN. comparative study on the problem drinking and job stress between employees who started drinking before and after the age of 19. The Journal of Kyungpook Nursing Science, (2004). 8(1), 17-30.

10. Park, HY, Jeon, JA, & Son, SJ. Gender Disparities in Typologies of Alcohol Use and Levels of Depressive Symptoms in Korean Adults. Mental Health & Social Work, (2015). 43(2), 176-99.

11. Tsukamoto, S, Kanegae, T, Saito, M, Nagoya, T, Shimamura, M, & Tainaka, H, et al. Concentrations of blood and urine ethanol, acetaldehyde, acetate and acetone during experimental hangover in volunteers. Arukoru Kenkyu-To Yakubutsu Ison Japanese Journal of Alcohol Studies & Drug Dependence, (1991). 26(6), 500-10.

12. Committee of Harrison’s principles of internal medicine. Harrison’s principles of internal medicine. 15th ed. Seoul. MIP;(2003). p. 2640-2.

13. Huh J. Donguibogam. Seoul. Namsandang;(1989). 131:p. 473p. 492p. 512p. 239-240. p. 431-432.

14. Wang B. Huangdineijing. Seoul. Gomunsa;(1972). p. 106-107. p. 193-194. p. 141p. 349

15. Meridians & Acupoints Compilation Committee of Korean Medical Colleges. Principles of Meridians & Acupoints; A Guidebook for College Students. Daejeon. JongRyeoNaMu Publishing Co;(2015). p. 40-3. p. 316

16. Huang di’s Canon of Medicine Recitation Book. Seoul. BuBinBooks;(2009). p. 160p. 500p. 574

17. Kim, YW. A Study on the SuHyeolLon of the Nan Gyeong. Journal of the Korea institute of oriental medical informatics, (2009). 15(1), 11-55.

18. OECD. Non-Medical Determinants of Health : Alcohol consumption. OECD Health Statistics 2015. Paris. OECD;(2015). p. 13

19. Kim GY. Drinking patterns impacting on prevalence risk of hypertension. Seoul. Graduate School of Seoul National University;(2015). p. 8

20. Professor of Liver System in Internal Medicine of Korean Medical Colleges. Liver System in Internal Medicine. Seoul. Dongyang medical Research center;(2001). p. 118-24.

21. Woo, SJ, Song, JC, Park, JM, & Kim, SW. The Effect of the Extract of Angelica gigas on the Serum Alcohol and Acetaldehyde Concentration in Rats. Korean J Orient Int Med, (2002). 23(2), 174-80.

22. French, KT. Biochemical basis for alcohol -induced liver injury. Chin, Biochem, (1989). 22, 41-9.

23. Jeong, YY, & Lee, YS. Protective Effect of Rhizoma Dioscoreae on the Gastric Mucosal Lesions Induced by Alcohol in Rats. Korean J Oriental Physiology & Pathology, (2009). 23(3), 639-44.

24. Wallace, RB, & Lynch, CF. Alcohol and consideration. Circulation, (1981). 64, 41-7.

25. Ko, SK, Yoo, HS, Kwon, YW, Kim, HCV, Kwon, KS, & Kim, JH. The effect of large quantities of alcohol ingestion on HPA axis, body temperature related circadian rhythm. Korea Journal of Sports Science, (2014). 23(1), 1101-11.

26. Gauvin, DV, Vanecek, SA, Baird, TJ, Briscoe, RJ, Vallett, M, & Holloway, FA. Genetic selection of alcohol preference can be countered by conditioning processes. Alcohol, (1998). 15(3), 199-206.

27. WHO. WHO Management of Drinking Problems. Geneva. WHO Regional Publications, European Series;(1990). p. 32

28. Kim BW. Liver System in Internal Medicine of Korean Medicine. Seoul. Jipmundang;(1986). p. 259

29. Hong, SW, Kim, JH, & Hwang, UW. Observation of Literatures on Observative Way to Damage to Drinking. J Korean Med, (1990). 11(2), 9-23.

30. Do, MH, Lee, SS, Jung, PJ, & Lee, MH. Relation of Breast Cancer Risk with Alcohol Consumption and Physical Activity: A Case-Control Study. Korean Journal of Nutrition, (2003). 36(1), 40-8.

31. Bae, JS, Kwak, J, Park, SK, Jang, SH, Yoo, KY, & Shin, HR. Cigarette Smoking;Alcohol Consumption; Tuberculosis and Risk of Lung Cancer: The Korean Multi-center Cancer Cohort Study. Journal of Preventive Medicine and Public Health, (2007). 40(4), 321-8.

32. Cho, SJ, Lee, HA, & Kim, OJ. Morphological Study on Acupuncture Meridian and Bonghan Ducts. Journal of Life Science and Natural resources Research, (2008). 30(2), 72-9.

33. Jung, DM, Lee, YH, Lee, SR, & Kim, KS. Implementation of the Visualizing System for Meridian by Overlapping with Bio-Signal and Image. Journal of the Korea Jungshin Science Society, (1999). 3(2), 133-40.

34. Noh, SH, Kim, KH, Yoon, YJ, Yang, GY, Kim, JK, & Lee, BR, et al. Ryodoraku Application for Diagnosis: a Review of Korean Literature. Korean Journal of Acupuncture, (2011). 28(4), 125-35.

35. Park, YB. The principle of Yangdorak and its clinical utilization. Journal of Hyun-Gok academic society, (1996). 1(2), 83-94.

36. Kim, SB, Kwon, SM, Myoung, HS, Lee, KJ, Kang, HJ, & Yim, YK, et al. Analysis of Meridian Energy and its Change Pattern with Time using Measurement of Skin-Capacitance on Source Points. Korean Journal of Acupuncture, (2009). 26(3), 1-11.

37. Lee, EA. Morphological Effect of Chronic Alcohol Drinking upon the Gastric Mucosa of Rats. Anatomy & Cell Biology, (2000). 33(5), 519-27.

38. Kim, YH, & Son, AR. The Relationship between Alcohol Drinking Behavior And High Blood Pressure. J of Korean Alcohol Science, (2009). 10(1), 81-92.

39. Lee KS. Cardiology and Neurology in Internal Medicine of Korean Medicine(Volume I). Seoul. SeoWongDang;(1995). p. 400-7.

40. Du HG. The Clinical Research of Kidney. Seoul. Seongbosa;(1995). p. 8-25.

41. Lee DY. Dong Yuan’s Ten Books. Seoul. DaeSeong Publishing;(1983). p. 55-57. p. 119

42. Kim KJ, Kim WH. The Theory and Clinical Use of Organ Study. Seoul. IlJungsa;(1996). p. 297-302.

43. Maeng, GH. Alcohol and Coronary heart Disease. Epidemiology and Health, (1993). 24, 113-8.

44. Goth Anderes. Medical Pharmacology. ST Louis. Mosby Company;(1984). p. 120

45. Yun, YH, Kim, SH, Lee, HJ, Lee, JH, & Kim, HT. Effects of Task Stressor, Noise Stimulus, Conifer Needle Odor and Soundguard on SCR, PPG and Behavioral Performance. Korean Journal of Clinical Psychology, (1997). 16(2), 435-45.