AbstractObjectivesThis study aimed to investigate the effect of banhasasim-tang intravenous herbal acupuncture (BST-IVHA) on emesis induced by chemotherapy in rats.
MethodsThis study used methotrexate(MTX)-induced Rat-Pica model. The rats were randomly allocated into seven groups; normal group, two saline groups, four Banhasasim-tang(BST) groups (groups treated with BST-IVHA). All the experimental animals except those in the normal group were injected with MTX. Those in the pre-treatment groups were treated with saline injection (saline group) or BST-IVHA (BST group) before MTX injection. Those in the post-treatment groups were treated with saline injection or BST-IVHA after MTX injection. Two different dosages of BST-IVHA solution (low dose; BST-1 group, high dose; BST-2 group) were used. The changes in body weight, food intake, and kaolin consumption at 24h, 48h, and 60h were monitored and analyzed.
Results1. No significant change was found in body weight. 2. The food intake at 48h was increased significantly in the BST-1 pre-treatment group(19.89±0.01g) compared to the pre-saline group(18.68±0.26g). 3. The kaolin consumption was significantly decreased in the BST-1 pre-treatment group at 24h(0.24±0.02g) and 60h(0.36±0.14g), in the BST-2 pre-treatment group at 48h(0.02±0.01g) and 60h(0.80±0.31g) compared to the pre-saline group(24h:0.81±0.37g, 48h:0.76±0.43g, 60h:1.56±0.03g). The kaolin consumption was also significantly decreased in the in the BST-1 post-treatment group at 24h(0.05±0.02g), 48h(0.64±0.06g) and 60h(0.14±0.05g), in the BST-2 post-treatment group at 48h(0.01±0.01g) and 60h(0.01±0.01g) compared to the post-saline group(24h:0.51±0.4g, 48h:3.58±0.33g, 60h:2.5±0.2g).
참고문헌1. Park JG, Park CI, Kim NK. Oncology. 1st ed. Seoul. Ilchokak;(2009). 3:p. 128
2. Graham, KM, Pecoraro, DA, Ventura, M, & Meyer, CC. Reducing the incidence of stomatitis using a quality assessment and improvement approach. Cancer Nurs, (1993). 16(2), 117-22.
![]() 3. Sonis, ST, Elting, LS, Keefe, D, Peterson, DE, Schubert, M, & Hauer-Jensen, M, et al. Perspectives on cancer therapy-induced mucosal injury: pathogenesis, measurement, epidemiology, and consequences for patients. Cancer, (2004). 100(9), 1995-2025.
![]() 4. Hockenberry-eaton, M, & Benner, A. Patterns of nausea and vomiting in children: nursing assessment and intervention. Oncol Nurs Forum, (1990). 17(4), 575-84.
5. Kim, HJ, & Kim, HS. Nausea/Vomiting and Self-care in patients with Cancer on Chemotherapy. J Korean Acad Funda Nurs, (2005). 12(2), 180-5.
6. Ackland, SP, & Schilsky, RL. High-dose methotrexate: a critical reappraisal. J Clin Oncol, (1987). 5(12), 2017-31.
![]() 7. Jacobs, SA, Stoller, RG, Chabner, BA, & Jones, DG. 7-Hydroxy methotrexate as a urinary metabolite in human subjects and rhesus monkeys receiving high-dose methotrexate. J Clin Incest, (1976). 57(2), 534-8.
![]() 8. Kim, SH, & Kim, DH. Traditional oriental medicine’s therapy on anticancer agent’s side effect. Daejeon University Journal of the institute of Oriental Medicine, (1993). 2(1), 32-51.
9. Bae BC. PyoJunImSangBangJeHak. Clinical Basic of Herb Prescription. Seoul. SeongBoSa;(1995). p. 123-5.
10. Meridians & Acupoints Compliation Committe of Korean Medical Colleges. Principles of Meridians & Acupoints; A Guidebook for College Students. 7th ed. Daejeon. JongRyeoNaMu Publishing;(2015). 101:p. 106
11. Yamamoto, K, Takeda, N, & Yamatodani, A. Establishment of an Animal Model for Radiation-induced Vomiting in Rats Using Pica. J Radiat Res, (2002). 43(2), 135-41.
![]() 13. Kim, W. Chemotherapy-induced nausea and vomiting. KSCO News&Education, (2008). 4, 24-9.
14. de Boer-Dennert, M, de Wit, R, Schmitz, PI, Djontono, J, v Beurden, V, & Stoter, G, et al. Patient perceptions of the side-effects of chemotherapy: the influence of 5HT3 antagonists. Br J Cancer, (1997). 76(8), 1055-61.
![]() 15. Kim, SG. Managements of Chemotherpay Induced Nausea and Vomiting. Korean J Clin Oncol, (2012). 8(1), 23-9.
![]() 16. Hornby, PJ. Central neurocircuitry associated with emesis. Am J Med, (2001). 111(Suppl 8A), 106S-12S.
![]() 17. Kris, MG, Radford, JE, Pizzo, BA, Inabinet, R, Hesketh, A, & Hesketh, PJ. Use of an NK1 receptor antagonist to prevent delayed emesis after cisplatin. J Natl Cancer Inst, (1997). 89(11), 817-8.
![]() 18. Jordan, K, Gralla, R, Jahn, F, & Molassiotis, A. International antiemetic guidelines on chemotherapy induced nausea and vomiting (CINV): Content and implementation in daily routine practice. Eur J Pharmacol, (2014). 722, 197-202.
![]() 19. Schwartzberg, L. Chemotherapy-induced nausea and vomiting: state of the art in 2006. J Support Oncol, (2006). 4(2 Suppl 1), 3-8.
20. Takahashi, T, Hoshi, E, Takagi, M, Katsumata, N, Kawahara, M, & Eguchi, K. Multicenter, phase II, placebo controlled, double-blind, randomized study of aprepitant in Japanese patients receiving high-dose cisplatin. Cancer Sci, (2010). 101(11), 2455-61.
![]() 21. Botrel, TE, Clark, OA, Clark, L, Paladini, L, Faleiros, E, & Pegoretti, B. Efficacy of palonosetron (PAL) compared to other serotonin inhibitors (5-HT(3)R) in preventing chemotherapy induced nausea and vomiting (CINV) in patients receiving moderately or highly emetogenic (MoHE) treatment: systematic review and meta-analysis. Support Care Cancer, (2010). 19(6), 823-32.
![]() 22. Saito, M, Aogi, K, Sekine, I, Yoshizawa, H, Yanagita, Y, & Sakai, H, et al. Palonosetron plus dexamethasone versus granisetron plus dexamethasone for prevention of nausea and vomiting during chemotherapy: a double-blind, double-dummy, randomised, comparative phase III trial. Lancet Oncol, (2009). 10(2), 115-24.
![]() 23. Shin, HS, Lee, SB, & Ryu, KH. Effect of Nei-Guan Acupressure on Nausea, Vomiting and Anorexia in Gynecological Cancer Patients Receiving Chemotherapy. J East-West Nurs Res, (2009). 15(1), 26-33.
24. Park, YK, Park, KI, Park, KS, Hwang, DS, Lee, CH, & Jang, JB, et al. A Clinical Study on Two Cases of Chemotherapy Induced Nausea and Vomiting (CINV) and Radiotherapy Induced Nausea and Vomiting (RINV) Patients Treated by Gamihachul-Tang-Gagam-bang. The Journal of Oriental Obstetrics & Gynecology, (2015). 28(3), 97-106.
25. Raghavendran, HR, Rekha, S, Shin, JW, Kim, HG, Wang, JH, & Park, HJ, et al. Effects of Korean ginseng root extract on cisplatin-induced emesis in a rat-pica model. Food and Chemical Toxicology, (2011). 49(1), 215-221.
![]() 26. Garcia, MK, McQuade, J, Haddad, R, Patel, S, Lee, R, & Yang, PY, et al. Systematic Review of Acupuncture in Cancer Care: A Synthesis of the Evidence. JCO, (2013). 31(7), 952-60.
![]() 27. Cheon, SY, Zhang, XY, Lee, IS, Cho, SH, Chae, YB, & Lee, HS. Pharmacopuncture for cancer care: a systematic review. Evidence-Based Complementary and Alternative Medicine, (2014). 2014, 804746.
![]() 28. Internal Medicine Professors of Korean Medical Colleges. Digestive system in Internal Medicine. Seoul. HanSeong Planning;(2000). p. 84-8.
29. Mun JJ, Ahn KS, Kim SH, Uhm HS, Ji GY, Kim SB. SangHanRonJeongHae. Interpretation of Treatise on Febrile Diseases. Seoul. Han UiMunHwaSa;(2003). p. 317-20.
30. Lee, JS, Kim, JS, Ryu, BH, & Yun, SH. Effect of Banhasasimtang Granule on Gastric Emptying in Rats. Korean J Orient Int Med, (2006). 27(2), 471-9.
31. Ryu, BH, Ryu, KW, Kim, JS, & Yun, SH. Evaluation for Therapeutic Effectiveness of Banwhasashim-tang in Functional Dyspepsia. Korean J Orient Int Med, (2003). 24(2), 329-36.
32. Jang, MU, & Im, SU. Experimental Study for Effect of Banhasasim-tang on Mice with Reflux Esophagitis. Korean J Orient Int Med, (2013). 34(4), 362-74.
33. Lee JH. DongUiImSangNaeGwaHak I. Clinical Internal Medicine of Oriental Medicine I. Seoul. BubIn Books;(1999). p. 271-8.
34. Takeda, N, Hasegawa, S, Morita, M, & Matsunaga, T. Pica in rats is analogous to emesis: an animal model in emesis research. Pharmacol Biochem Behav, (1993). 45(4), 817-21.
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