Exploratory Structural Analysis on Eight Positions for New Formulations in Jingyuequanshu by Network Analysis

Yunkyeong Jeong; Hyungsuk Kim; Hyunho Kim; Young-jae Park; Young-bae Park; Jeong, Yunkyeong; Kim, Hyungsuk; Kim, Hyunho; Park, Young-jae; Park, Young-bae

doi:10.13048/jkm.14030

JKM > Volume 35(3); 2014 > Article

Jeong, Kim, Kim, Park, and Park: Exploratory Structural Analysis on Eight Positions for New Formulations in Jingyuequanshu by Network Analysis

Original Article

Journal of Korean Medicine 2014; 35(3): 49-59.

Published online: September 30, 2014

DOI: https://doi.org/10.13048/jkm.14030

Exploratory Structural Analysis on Eight Positions for New Formulations in Jingyuequanshu by Network Analysis

Yunkyeong Jeong¹, Hyungsuk Kim¹, Hyunho Kim², Young-jae Park², Young-bae Park²

¹College of Korean Medicine College, Kyung Hee University, Seoul, Korea

²Department of Biofunctional Medicine & Diagnostics, College of Korean Medicine, Kyung Hee University, Seoul, Korea

Equal contributor:

* Yunkyeong Jeong and Hyungsuk Kim contributed to this paper equally.

Correspondence to: 박영배 (Young-bae Park), 서울시 동대문구 회기동 경희대학교 한의과대학 진단ㆍ생기능의학과 Tel : +82-2-958-9240, Fax : +82-2-958-9241, E-mail : bmppark@khu.ac.kr

Received June 26, 2014 Revised August 20, 2014 Accepted August 20, 2014

Abstract

Background:

Eight positions for new formulations in Jingyuequanshu is a unique classifying system and each position can be presented as a network. Network analysis is an effective method of visualizing the relationship of textual information.

Purpose:

This study aimed to analyze the structure of the eight positions for new formulations in Jingyuequanshu, and to acquire information about composing materia medica.

Methods:

We constructed an initial database and binary matrix of eight positions for new formulation in Jingyuequanshu, including its herbs and formulations. With this data, we carried out frequency and network analysis.

Results:

We analyzed each of the eight positions for new formulation, entire positions, and five positions after removing ‘causal/cold/hot’ positions. We found that the formulas of the causal position are distributed throughout the new formulation, and those of the cold and hot positions are also distributed similarly but the two groups are exclusive to each other. The other 5 positions are distributed exclusively to one another.

Conclusions:

Eight positions for new formulation of Jingyuequanshu were classified into three axes by exploratory network analysis. One is an axis of causal position, another is an axis of cold/hot positions, and the last is an axis of the other five positions.

Keywords: network analysis, Jingyuequanshu, eight positions for new formulation, Korean medicine, Zhang Jingyue

Fig. 1.

Initial data structure of eight positions of new formulation in Jingyuequanshu

Fig. 2.

Binary matrix of formulation and herbs

Fig. 3.

Network analysis of the entire formula

Fig. 4.

Network analysis of seven positions after removing ‘causal position’

Fig. 5.

Network analysis of five positions after removing ‘causal, cold, and hot positions’

Fig. 6.

Network analysis of the each combination of the five positions

Fig. 7.

Network analysis of cold position and hot position

Table 1.

Network and Frequency Analysis of Each Position

Position	# of formula	Main Herbs	Frequency of herbs	Ratio (%)
Tonifying (補陣)	29	Rehmanniae Radix Preparat(숙지황)	22	75.9
		Angelicae Gigantis Radix(당귀)	14	48.3
		Lycii Fructus(구기자)	12	41.4
		Dioscoreae Rhizoma(산약)	11	37.9
		Ginseng Radix(인삼)	10	34.5

Harmonizing (和陣)	20	Citri Pericarpium(진피)	14	70.0
		Poria(백복령)	10	50.0
		Magnoliae Cortex(후박)	9	45.0
		Alismatis Rhizoma(택사)	8	40.0
		Pinelliae Rhizoma(반하)	6	30.0

Attacking (攻陣)	5	Aucklandiae Raidx(목향)	3	60.0
		Gleditsiae Spina(조각자)	3	60.0
		Calomelas(경분)	2	40.0
		Linderae Radix(오약)
		Caryophylli Flos(정향)
		Citri Pericarpium(진피)
		Alismatis Rhizoma(택사)
		Crotonis Fructus(파두)

Dispersing (散陣)	17	Bupleuri Radix(시호)	13	76.5
		Angelicae Gigantis Radix(당귀)	7	41.2
		Citri Pericarpium(진피)	7	41.2
		Zingiberis Rhizoma(생강)	5	29.4

Cold (寒陣)	20	Alismatis Rhizoma(택사)	8	40.0
		Paeoniae Radix Alba(백작약)	7	35.0
		Scutellariae Radix(황금)	7	35.0
		Akebiae Caulis(목통)
		Rehmanniae Radix(생지황)	6	30.0

Heat (熱陣)	25	Zingiberis Rhizoma(건강)	19	76.0
		Ginseng Radix(인삼)	12	48.0
		Poria(백복령)	8	32.0
		Aconiti Lateralis Preparata
		Radix(부자)
		Angelicae Gigantis Radix(당귀)	7	28.0
		Atractylodis Rhizoma White(백출)
		Rehmanniae Radix Preparat(숙지황)

Securing (固陣)	10	Schizandrae Fructus(오미자)	6	60.0
		Poria(백복령)	5	50.0
		Atractylodis Rhizoma White(백출)
		Dioscoreae Rhizoma(산약)
		Cuscutae Semen(토사자)
		Polygalae Radix(원지)	3	30.0
		Ginseng Radix(인삼)	3	30.0

Causal (因陣)	60	Angelicae Gigantis Radix(당귀)	26	43.3
		Paeoniae Radix Alba(백작약)	17	28.3
		Rehmanniae Radix Preparat(숙지황)	14	23.3
		Cnidii Rhizoma(천궁)	9	15.0
		Cinnamomi Cortex(육계)	8	13.3

Table 2.

Frequency Analysis of the Entire Formulas

# of formula	Main Herbs	Frequency	Ratio(%)
186	Angelicae Gigantis Radix(당귀)	57	30.6
	Rehmanniae Radix Preparat(숙지황)	51	27.4
	Citri Pericarpium(진피)	42	22.6
	Poria(백복령)	41	22.0
	Paeoniae Radix Alba(백작약)	39	21.0
	Ginseng Radix(인삼)	33	17.7
	Atractylodis Rhizoma White(백출)	31	16.7
	Zingiberis Rhizoma(건강)	29	15.6
	Alismatis Rhizoma(택사)	27	14.5
	Dioscoreae Rhizoma(산약)	23	12.4

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