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JKM > Volume 35(1); 2014 > Article
Song, Lee, Yoo, Lee, Koh, Bu, Park, Kim, and Chai: The Study for standardized Method of the Retention-Enema; For a Method of Experimental Study

Abstract

Objectives

This study was to propose a standardized method of retention enema by extracting elements associated with published experimental methods of retention enema.

Methods:

1) Literature search (1) Data sources: Retrieval was made, using ‘Enema’ or ‘Retention Enema’ as search words in Medline, Cochrane library, KISS, RISS, and KDSL DB. (2) Study selection: Two authors excluded irrelevant papers and chose qualified abstracts from the rest of the papers. The chosen studies were reviewed fully by the authors so that they could screen the significant papers based on the exclusion criteria. (3) Data extraction: Data on the total number of subjects, the target disease, the animal species, the type, quality, length, and diameter of catheter, the insertion length of catheter, the sample, the sample volume, the process of retention enema and the number of retention enemas performed were extracted from the selected studies. 2) Performing preliminary experiments about the elements associated with experimental methods of retention enema.

Results & Conclusions:

The standardized experimental method is as follows: animal: 280–320g SD rat 1) inserting a rectal tube of 8 Fr that measures 8 cm into the animal’s anus, 2) injecting herbal medicines at the volume of 6 ml and 3) holding them for 10 minutes.

Fig. 1
The flow chart for selecting the proper papers for this study
jkm-35-1-1-1f1.tif
Fig. 2
The basic setting of retention enema
jkm-35-1-1-1f2.tif
Table 1
The Result of Searching Human Study about ‘Enema’ or ‘Retentionenema’ or ‘Analtherapy’
Author (year) subject disease Animal (Species;BW) No. of subjects The kind, quality of the material and diameter of catheter The insertion length of catheter Sample volume Sample Retention time The method of retention enema The number of acting retention enema
E. Gaudier et al. (2009)8) - mice; 22.8±0.2g 40 2.4cm steel cannula - 100μl 100 mM butyrate 10min After anesthetizing mice mild, vertical position, head down, instillating sample 1 time/day, during 7days
H. Yuceyar et al. (1999)9) Colitis Wistar Albino rats; 180–210g 50 rubber annular 7cm, diameter 2mm - 0.25ml a solution containing 30 mg of trinitrobenzene sulphonic acid 30sec - 1 time/day
Lee GU et al. (1998)11) Anaphylaxis ICR mouse; - 120 stomach sonde - 40μl Sochungyong decotion - After instillating sample, applying glue to anus 1 time/day
Mustafa sahin et al. (1998)10) Pancreatitis SD rat; 210±22g 23 8F feeding catheter 2–3cm 10ml/200g sodium hydrogen phosphatesolutio ns - Just instillating sample by catheter 1 time/5h, 24h, 48h after colitis inducing
M. Machado et al. (2007)5) Colitis male Wistar rats; 250–300g 50 6Fr polyethylene catheter (1F:0.33mm) - 1ml Budesonida(1mg/ml)/probiotics(1mg/ml) 30sec After intillating sample, suspendering rat. 1 time/day,
Song-Ming Guo et al. (2004)12) Colitis Wistar rats; 200±20g 56 nylon hose 8cm 2ml traditional Chinese medicinal herbs* 15sec Just instillating sample by nylon hose 1 time/day, during 28 days
TAKAKO NAKASHIMA et al. (2005)14) Colitis SD rat; approximately 250g. 60 - 6cm 1mL/kg 0.3%, 1% Rebamipide - - 2 time/day, during 14 days
Tomohisa et al. (2010)13) Ulceration Male Wistar rats; 180–200g 20 - - 2ml/kg 4% Ecabet sodium - - 2times /day, during 7days
Yu You et al. (2009)15) Colitis 8-week-old male Balb/c mice; - 50 - - 3ml/20g N-acetylcysteine - - 1 time/day
Zo JY et al. (2002)16) Anaphylaxis ICR mouse, & Wister rat; - 24 stomach sonde - 40μl Okbyungfung-san decotion - After instillating sample, applying glue to anus 1 time/day

* Huangqi (astragalus), Dahuang (caulisfibraureae), Huangbai (cortex phellodendri), Wubeizi (gallachinensis) and Baiji (rhizoma bletillae)

참고문헌

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9. Yuceyar H, Ozutemiz O, Huseyinow A, Saruc A, Alkanat M, Bor S, et al. Is Administration of n-3 fatty acids by Mucosal Enema Protective against Trinitrobenzene-induced Colitis in rats? Prostaglandins, Leukotrienes and Essential Fatty Acids. 1999; 61:6. 339–345.
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13. Tomohisa T, Yuji N, Toshimitsu O, Kazuhiko U, Satoko A, Latsura M, et al. Ecabet Sodium Promotes the Healing of Trinitrobenzene-sulfonic-acid-induced Ulceration by Enhanced Restitution of Intestinal Epithelial Cells. Journal of Gastroenterology and Hepatology. 2010; 25:1259–265.
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21. Lee HS, Jin SK, Choi JH, Ku YS. Rectal Absorption of Acetaminophen from Polyethylene Glycol and Witepsol Suppositories. Korean J. Clin. Pharm. 1998; 8:2. 143–146.


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