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JKM > Volume 34(3); 2013 > Article
Kim and Lee: The Effect of Mild Cognitive Impairment Management Program on Traditional Korean Medicine in a Public Health Center

Abstract

Objectives:

The aim of this study was to evaluate the effect of a mild cognitive impairment (MCI) management program on traditional Korean medicine in a public health center.

Methods:

In order to examine the effect of the MCI management program, we investigated MCI patients who participated in the program. MCI patients were treated with Jodeung-san (JDS) or Dangguijagyag-san (DGJYS) for 6 weeks. Mini Mental State Examination-Dementia Screening (MMSE-DS), Geriatric Quality of Life-Dementia (GQOL-D), Geriatric Depression Scale in Korea (GDS-K), and biochemical examination of blood were conducted at intervals of 6 weeks. A satisfaction survey was collected after this program.

Results:

MMSE-DS mean score increased significantly, by 4.09 (p=0.000) in the JDS group and by 4.15 (p=0.000) in the DGJYS group. GQOL-D mean score also increased significantly, by 5.90 (p=0.000) in the JDS group and by 5.07 (p=0.000) in the DGJYS group. GDS-K mean score decreased significantly, by 10.63 (p=0.000) in the JDS group and by 9.69 (p=0.000) in the DGJYS group. MMSE-DS, GDS-K and GQOL-D scores were not significantly different between the JDS and DGJYS groups. All of the participants were satisfied with the program, and 90% of the participants expressed a high intention to participate in the program again.

Conclusions:

Both Jodeung-san and Dangguijagyag-san treatment showed improvement on cognitive function, depression and quality of life in this program. Additional studies with more subjects will be required to prove credibility and validity more clearly.

Fig. 1.
Change of MMSE-DS Scores with the Program
jkm-34-3-106-9f1.tif
Fig. 2.
Change of GDS-K Scores with the Program
jkm-34-3-106-9f2.tif
Fig. 3.
Change of GQOL-D Scores with the Program
jkm-34-3-106-9f3.tif
Fig. 4.
Satisfaction after the Program
jkm-34-3-106-9f4.tif
Fig. 5.
Changes in perception of MCI after the Program
jkm-34-3-106-9f5.tif
Fig. 6.
Re-participation Intention after the Program
jkm-34-3-106-9f6.tif
Table 1.
Composition of JDS
Composition Amount Unit
JDS extract contain dried extract of the following mixed crude drugs 1.5 g
Gypsum 1.7 g
Uncaria Hook 1.0 g
Citrus Unshiu Peel 1.0 g
Ophiopogon Tuber 1.0 g
Pinellia Tuber 1.0 g
Poria Sclerotium 1.0 g
Chrysanthemum Flower 0.7 g
Ginseng 0.7 g
Saposhnikovia Root 0.7 g
Glycyrrhiza 0.3 g
Ginger 0.3 g
Lactose Hydrate 0.9875 g
Magnesium Stearate 0.0125 g

Total 2.5 g
Table 2.
Composition of DGJYS
Composition Amount Unit
DGJYS extract contain dried extract of the following mixed crude drugs 1.0 g
Peony Root 1.0 g
Atractylodes Lancea Rhizome 1.0 g
Alisma Rhizome 1.0 g
Poria Sclerotium 1.0 g
Cnidium Rhizome 0.75 g
Japanese Angelica Root 0.75 g
Lactose Hydrate 0.86562 g
Magnesium Stearate 0.00938 g

Total 1.875 g
Table 3.
Charateristics of Subjects
Variables JDS Group DGJYS Group Total

N % N % N %
Sex Male 3 27.3 2 15.4 5 20.8
Female 8 72.7 11 84.6 19 79.2
Total 11 100 13 100 24 100

Age 73.91±2.98 73.92±3.77 73.92±3.17
Education level 4.55±4.01 2.85±3.98 3.63±3.94
MMSE-DS 20.55±2.62 19.23±2.83 19.83±2.76
GDS-K 22.27±3.95 21.23±5.57 21.71±4.82
GQOL-D 21.55±3.11 20.85±3.74 21.17±3.41
Table 4.
Change of MMSE-DS Scores with the Program
MMSE-DS Mean Std. Deviation t Sig.(2-tailed)

JDS DGJYS Total JDS DGJ YS Total JDS DGJYS Total JDS DGJYS Total
Orientation Before 8.45 7.69 8.04 1.44 1.70 1.61 −2.14 −2.41 −3.29 0.058 0.033* 0.003**
After 9.45 8.85 9.12 0.69 1.07 0.95
Attention Before 1.64 1.08 1.33 1.43 1.32 1.37 −2.89 −3.09 −4.29 0.016* 0.009** 0.000**
After 2.55 2.15 2.33 1.04 1.86 1.52
Memory Before 4.18 4.15 4.17 0.98 0.90 0.92 −1.17 −2.21 −2.4 0.267 0.047* 0.024*
After 4.55 4.69 4.63 1.04 0.95 0.97
Language Before 4.00 4.46 4.25 0.77 0.78 0.79 −7.06 −3.86 −7.0 0.000** 0.002** 0.000**
After 5.45 5.38 5.42 0.69 0.65 0.65
Visuospatial ability Before 0.45 0.15 0.29 0.52 0.38 0.46 −1.49 −1.48 −2.15 0.167 0.165 0.043*
After 0.64 0.31 0.46 0.50 0.48 0.51
Judgement Before 1.82 1.77 1.79 0.40 0.44 0.41 −1.49 −1.90 −2.46 0.167 0.082 0.022*
After 2.00 2.00 2.00 0.00 0.00 0.00
Total Before 20.55 19.23 19.83 2.62 2.83 2.76 −5.59 −7.22 −9.21 0.000** 0.000** 0.000**
After 24.64 23.38 23.96 1.75 1.80 1.85

* p<0.05,

** p<0.01

Table 5.
Change of GDS-K Scores with the Program
GDS-K
Mean Std. Deviation t Sig.(2-tailed)
JDS Group Before 22.27 3.95 9.92 0.000**
After 11.64 4.57
DGJYS Group Before 21.23 5.57 8.00 0.000**
After 11.54 4.94
Total Before 21.71 4.82 12.53 0.000**
After 11.58 4.67

* p<0.05,

** p<0.01

Table 6.
Change of GQOL-D Scores with the Program
GQOL-D
Mean Std. Deviation t Sig.(2-tailed)
JDS Group Before 21.55 3.11 −7.26 0.000**
After 27.45 3.88
DGJYS Group Before 20.85 3.74 −5.06 0.000**
After 25.92 4.01
Total Before 21.17 3.41 −8.38 0.000**
After 26.63 3.94

* p<0.05,

** p<0.01

Table 7.
Difference of Scores between JDS and DGJYS Group
Mean Difference Std. Deviation F Sig.(2-tailed)
MMSE-DS JDS Group 4.09 2.43 0.097 0.758
DGJYS Group 4.15 2.08
GQOL-D JDS Group 5.91 2.70 0.028 0.868
DGJYS Group 5.08 3.62
GDS-K JDS Group −10.64 3.56 0.215 0.648
DGJYS Group −9.69 4.37

* p<0.05,

** p<0.01

Table 8.
Change of biochemical examination of blood with the Program
JDS Group DGJYS Group

M±SD Sig.(2-tailed) M±SD Sig.(2-tailed)
AST Before 27.09±10.92 0.592 25.31±7.81 0.335
After 25.73±18.82 23.15±3.76
ALT Before 18.82±9.52 0.471 19.31±7.34 0.829
After 19.82±6.43 18.85±5.51
rGPT Before 42.82±43.62 0.913 36.31±46.00 0.114
After 41.45±60.26 33.54±44.58
BUN Before 16.06±3.29 0.260 14.55±3.74 0.472
After 18.11±6.20 15.54±3.05
Creatinine Before 0.94±0.25 0.736 0.84±0.12 0.223
After 0.92±0.30 0.78±0.18
Uric acid Before 5.63±1.45 0.346 5.13±1.18 0.069
After 5.30±0.82 4.84±1.01

* p<0.05,

** p<0.01

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