| ORIGINAL ARTICLE |
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J Korean Med. 2013;34(1): 89-102.
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| Effects of Root of Curcumin longa on LPS-induced Lung Injury |
| Ji-Seok 1, Su-Young Yang1, Min-Hee Kim2, Uk Namgung2, and Yang-Chun Park1 |
1Division of Respiratory System, Dept. of Internal Medicine, College of Oriental Medicine, Daejeon University
2Dept. of Neurophysiology, College of Oriental Medicine, Daejeon University |
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| Corresponding Author:
Yang-Chun Park ,Tel: +82-42-229-6919, Fax: +82-42-254-3403, Email: omdpyc@dju.kr |
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Received: August 17, 2012; Accepted: October 31, 2012. |
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| ABSTRACT |
Objectives: This study aimed to evaluate the effects of root of Curcumin longa (RCL) on LPS-induced COPD (chronic
obstructive pulmonary disease) model.
Materials and Methods: Extract of RCL was treated to RAW 264.7 cells and LPS-induced COPD mouse model. Then,
various parameters such as cell-based protective activity, airflow limitation, accumulation of immune cells and
histopathological finding were analyzed.
Results: RCL showed a protective effect on LPS-induced cytotoxicity in RAW 264.7 cells. RCL treatment also revealed
a protective effect on LPS-induced lung injury in a COPD mouse model. This effect was demonstrated via the reduction
of accumulation of immune cells and pathophysiological regulation of caspase 3, elastin and collagen in lung tissue.
Conclusions: These data suggest that RCL has a pharmaceutical property on lung injury. This study provides scientific
evidence for the efficacy of RCL for clinical application to COPD patients. |
| Keywords:
Root of Curcumin longa | chronic obstructive pulmonary disease | emphysema | RAW 264.7 cells |
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