ORIGINAL ARTICLE |
J Korean Med. 2013;34(1): 1-14.
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The Effects of Platycodi Radix on Obese Type 2 Diabetes Mouse Model
Induced by High Fat, High Carbohydrate Diet |
Oh-Jun Kwon, Seung-Wook Lee, Sun-Ho Paik, Su-Ryun Han, Young-Min Ahn, Se-Young Ahn, and Byung-Cheol Lee |
Dept. of Internal medicine, College of Oriental Medicine, Kyung Hee University |
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Corresponding Author:
Byung-Cheol Lee ,Tel: +82-2-958-9182, Fax: +82-2-958-9158, Email: hydrolee@korea.com |
Received: May 4, 2012; Accepted: September 12, 2012. |
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ABSTRACT |
Objectives: This study was designed to investigate the anti-obesity, anti-diabetic and anti-inflammatory effects of
Platycodi radix on obese type 2 diabetes mouse model.
Methods: Obese type 2 diabetes mouse model was induced by Surwit's high fat, high sucrose diet for 8 weeks. Models
were divided into 4 groups of normal diet (ND, n=10), high fat and high sucrose diet (HFD, n=10), high fat and high
sucrose diet with Platycodi radix (PR, n=10), and high fat and high sucrose diet with Metformin (Met, n=10). Body
weights were measured every week. After 7 weeks fasting, blood sugar and oral glucose tolerance tests were conducted.
After 8 weeks blood samples were taken from mouse hearts and analyzed biochemically. Lipid profile, fructosamine,
leptin and weight of epididymal fat pad and liver were measured. Adipose tissue macrophage percentage was analyzed
by fluorescence-activated cell sorting (FACS).
Results: Compared with the HFD group, body weight, glucose level, fructosamine, weight of epididymal fat pad and
adipose tissue macrophage percentage decreased in the PR group.
Conclusions: These results suggest that Platycodi Radix has anti-obesity, anti-diabetic, and anti-inflammatory effects on
obese type 2 diabetes mouse model. |
Keywords:
Platycodi radix | Type 2 Diabetes | Obesity | Inflammation | Insulin resistance |
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