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ORIGINAL ARTICLE
J Korean Med. 2012;33(4): 26-36.
Analysis of Biological Experiments on the Anti-inflammatory and Antipyretic Effects of Hwangryeonhaedok-tang
Jung-Hoon Kim, and Hyeun-Kyoo Shin
Basic Herbal Medicine Research Group, Korea Institute of Oriental Medicine
Corresponding Author: Hyeun-Kyoo Shin ,Tel: +82-42-868-9464, Fax: +82-42-864-2120, Email: hkshin@kiom.re.kr
Received: September 27, 2012;  Accepted: November 26, 2012.
ABSTRACT
Objectives: To establish scientific and objective evidence for the use of a Korean medicine, articles regarding Hwangryeonhaedok-tang (HRHDT), a herbal medicine frequently used in Korean medical clinics and hospitals, were gathered and analyzed.
Methods: The articles were classified as being from domestic or international journals, and by their year of publication. The mechanisms of the anti-inflammatory and antipyretic effects of HRHDT were investigated.
Results: Of the 25 articles analyzed, 7 were published from Korea, 7 were from China, and 11 were from Japan. HRHDT showed anti-inflammatory and antipyretic effects through the regulation of the expression of Th1 cytokines including interleukin-2 (IL-2), IL-8, interferon-款 (IFN-款), and tumor necrosis factor-慣 (TNF-慣); and Th2 cytokines including IL-4, IL-6, and IL-12, which inhibit leukotriene B4 (LTB4), cyclooxygenase-2 (COX-2), prostaglandin E2 (PGE2), and inflammatory cells. It also lowered preprodynorphin (PPD), and corticotropin-releasing factor (CRF) in the peripheral nerve system and hypothalamus.
Conclusions: We speculate that the anti-inflammatory and antipyretic effects could be related to the therapeutic efficacy of HRHDT in removing pathogenic fire and heat.
Keywords: Hwangryeonhaedok-tang (HRHDT) | evidence | anti-inflammatory | antipyretic | therapeutic efficacy
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