Clinical Effectiveness of Ikgibohyeol-tang(Yìqìbǔxuè-tāng) and Deer Antler on Fatigue Symptoms and HRV Results in Outpatients at Korean Medical Hospital: A Retrospective Chart Review Study

Won Jung Ha; Sang-Kwan Moon; Han-Gyul Lee; Seung-Yeon Cho; Seong-Uk Park; Woo-sang Jung; Jung-Mi Park; Chang-Nam Ko; Ki-Ho Cho; Seungwon Kwon; Ha, Won Jung; Moon, Sang-Kwan; Lee, Han-Gyul; Cho, Seung-Yeon; Park, Seong-Uk; Jung, Woo-sang; Park, Jung-Mi; Ko, Chang-Nam; Cho, Ki-Ho; Kwon, Seungwon

doi:10.13048/jkm.22036

JKM > Volume 43(3); 2022 > Article

Ha, Moon, Lee, Cho, Park, Jung, Park, Ko, Cho, and Kwon: Clinical Effectiveness of Ikgibohyeol-tang(Yìqìbǔxuè-tāng) and Deer Antler on Fatigue Symptoms and HRV Results in Outpatients at Korean Medical Hospital: A Retrospective Chart Review Study

Original Article

The Journal of Korean Medicine 2022; 43(3): 139-149.

Published online: September 1, 2022

DOI: https://doi.org/10.13048/jkm.22036

Clinical Effectiveness of Ikgibohyeol-tang(Yìqìbǔxuè-tāng) and Deer Antler on Fatigue Symptoms and HRV Results in Outpatients at Korean Medical Hospital: A Retrospective Chart Review Study

Won Jung Ha¹

, Sang-Kwan Moon^1,2

, Han-Gyul Lee^1,2

, Seung-Yeon Cho^1,2

, Seong-Uk Park^1,2

, Woo-sang Jung^1,2

, Jung-Mi Park^1,2

, Chang-Nam Ko^1,2

, Ki-Ho Cho^1,2

, Seungwon Kwon^1,2^{, *}

¹Dept. of Clinical Korean Medicine, Graduate school, Kyung-Hee University

^1,2Dept. of Cardiology and Neurology, College of Korean medicine, Kyung-Hee University

Correspondence to: Seungwon Kwon, KyungHeeDaeRo 23, KyungHee University Korean Medicine Hospital, Dongdaemun-Gu, Tel : +82-2-958-9190, Fax : +82-2-958-9132, E-mail : kkokkottung@hanmail.net

Received July 20, 2022 Revised August 9, 2022 Accepted August 16, 2022

Abstract

Objectives

This study was designed to investigate the clinical effectiveness of Ikgibohyeol-tang(Yìqìbǔxuè-tāng) granules and Deer antler granules on fatigue symptoms.

Methods

This is a 39-patient case series from a retrospective chart review of outpatients who were treated with Ikgibohyeol-tang granules and Deer antler granules at a Kyung Hee University Korean Medicine Hospital (Seoul) between 1st, January 2015 to 1st, August 2021. We reviewed the patients who complained of fatigue and analyzed changes in the degree of discomfort with fatigue and accompanying symptoms and HRV (Heart Rate Variability) score before and after treatment.

Results

After taking Ikgibohyeol-tang granules and Deer antler granules, the degree of discomfort with fatigue and accompanying symptoms decreased significantly compared to before taking them. After treatment, Autonomic nervous system activity, Stress resistance, Heart Stability increased, and Stress index, Degree of fatigue decreased significantly.

Conclusions

This study showed subjective symptoms and objective indicator (HRV score) were improved by taking Ikgibohyeol-tang granules and Deer antler granules.

Keywords: Ikgibohyeol-tang, Deer antler, Fatigue, HRV

Fig. 1

The remaining degree of discomfort with fatigue and accompanying symptoms after treatment.

Fig. 2

Comparison of differences in HRV scores before and after IGBHT granules and Deer antler granules administration (*p<.05, **p<.01, ***p<.001). HRV, Heart Rate Variability; ANS, Autonomic nervous system

Table 1

Composition of IGBHT granules per pack

Scientific name of Herb	Dose(g)
Atractylodis Rhizoma alba	5.264
Astragali Radix	5.264
Hoelen	3.506
Pinelliae Rhizoma	3.506
Massa Medicata Fermentata	3.506
Crataegi Fructus	3.506
Glycyrrhizae Radix	3.506
Cyperi Rhizma	3.506
Aurantii Nobilis Pericarpium	3.506
Hordei Fructus Germinatus	3.506
Magnoliae Cortex	2.805
Amomi Semen	2.805
Paeoniae Radix	2.459
Angelicae Gigantis Radix	2.459
Rehmanniae Radix	2.459
Poria Sclertum cum Pini Radix	2.104
Liriopis Tuber	2.104
Polygalae Radix	2.104
Gingseng Radix	2.104
Cnidium officinale Makino	1.870
Saussureae Radix	1.870
Zingiberis Rhizoma	3.506
Zizyphi Fructus	3.740

* IGBHT, Ikgibohyeol-tang; IGBHT granules were made by the Korean Medicine Pharmacy Department of Kyung Hee University Korean Medicine Hospital.

Table 2

Composition of Deer antler granules per pack

Scientific name of Herb	Dose(g)
Cervi Parvum Cornu	12

* Deer antler granules were made by the Korean Medicine Pharmacy Department of Kyung Hee University Korean Medicine Hospital.

Table 3

Past medical history of patients

Past history	Number (%)
Hypertension	19 (48.7)
Diabetes Mellitus	1 (2.6)
Dyslipidemia	14 (35.9)
Cerebrovascular disease	7 (17.9)
Cardiovascular disease	2 (5.1)
Thyroid disease	5 (12.8)
Liver disease	1 (2.6)
Musculoskeletal disease	7 (17.9)
Gynecological disease	5 (12.8)

Table 4

Main impression of patients

Main impression	Number (%)
Headache	7 (17.9)
Dizziness and giddiness	6 (15.4)
Paresthesia of skin, Numbness	3 (7.7)
Cerebral infarction	2 (5.1)
Cervicalgia	2 (5.1)
Other and unspecified primary hypertension	2 (5.1)
Fatigue	2 (5.1)
Dementia in Alzheimer's disease	1 (2.6)
Disorder of brain	1 (2.6)
Insomnia	1 (2.6)
Orthostatic hypotension	1 (2.6)
Tremor	1 (2.6)
Dystonia	1 (2.6)
Muscle cramp	1 (2.6)
Gait disturbance	1 (2.6)
Edema	1 (2.6)
Disturbances of skin sensation	1 (2.6)
Sequelae of cerebral infarction	1 (2.6)

Table 5

Chief complaint of patients accompanied with fatigue

Chief complaint accompanied with fatigue	Number (%)
Headache group	9 (23.1)
Paresthesia group	8 (20.5)
Dizziness group	7 (17.9)
Movement Disorder group	6 (15.4)
Neuropsychiatric symptom group	6 (15.4)
Nonspecific symptom group	3 (7.7)

Table 6

Change of HRV scores after IGBHT granules and Deer antler granules administration

Change of HRV scores	ANS activity	Balance of the ANS	Stress resistance	Stress index	Degree of fatigue	Heart Stability
Improvement to the different range	17 (43.6)	11 (28.2)	20 (51.3)	18 (46.2)	20 (51.3)	14 (35.9)
Change within the same range	17 (43.6)	20 (51.3)	14 (35.9)	18 (46.2)	14 (35.9)	22 (56.4)
Worsen to the different range	5 (12.8)	8 (20.5)	5 (12.8)	3 (7.7)	5 (12.8)	3 (7.7)

* Number (%) values are shown.

HRV, Heart Rate Variability; IGBHT, Ikgibohyeol-tang; ANS, Autonomic nervous system

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