A Clinical Research about Herbal Cosmetics Containing Caffeic acid phenethyl ester Isolated from Vespae Nidus on the Whitening Effects

Ho-Yeol Cha; Hee-Yeon Kim; Ki-Tae Ha; Jin-Hong Cheon; Kibong Kim; Cha, Ho-Yeol; Kim, Hee-Yeon; Ha, Ki-Tae; Cheon, Jin-Hong; Kim, Kibong

doi:10.13048/jkm.17027

JKM > Volume 38(3); 2017 > Article

Cha, Kim, Ha, Cheon, and Kim: A Clinical Research about Herbal Cosmetics Containing Caffeic acid phenethyl ester Isolated from Vespae Nidus on the Whitening Effects

Original Article

The Journal of Korean Medicine 2017; 38(3): 86-95.

Published online: September 30, 2017

DOI: https://doi.org/10.13048/jkm.17027

A Clinical Research about Herbal Cosmetics Containing Caffeic acid phenethyl ester Isolated from Vespae Nidus on the Whitening Effects

Ho-Yeol Cha¹, Hee-Yeon Kim¹^{, 2}, Ki-Tae Ha², Jin-Hong Cheon¹^{, 2}, Kibong Kim¹^{, 2}

¹Department of Pediatrics of Korean Medicine, Pusan National University Hospital

²School of Korean Medicine, Pusan National University

Correspondence to：김기봉(Kibong Kim) Department of Korean Pediatrics, Hospital of Korean Medicine, Pusan National University, Geumo-ro 20, Mulgeum-eup, Yangsan-si, Gyeongsangnam-do, 50612, Rep. of Korea. Tel：+82-55-360-5952, Fax：+82-55-360-5952, E-mail : kkb2630@gmail.com

Received August 16, 2017 Revised September 18, 2017 Accepted September 18, 2017

Abstract

Objectives

The purpose of this clinical research was to investigate the effects of herbal cosmetics containing Caffeic acid phenethyl ester (CAPE), an ingredient compound of various herbs including Vespae Nidus, on the Whitening Effects.

Methods

A total of 20 subjects who visited Pusan National University Hospital from March 2nd, 2017 to April 11th, 2017 were included. In this study, we evaluated the visual evaluation, the melanin index (M) and erythema index (E) through skin analysis equipment, the subjective whitening improvement analysis, and the adverse reaction according to product use. Statistical analysis was performed with independent t-test and Mann-Whitney’s U test. Statistical significance was achieved if the probability was less than 5% (p<0.05)

Results

As a result of the visual evaluation, it was effective in improving skin whitening. The subjective whitening improvement analysis also showed positive results. However, no statistically significant differences were found between the test and control cosmetics in the melanin index (M) and erythema index (E) through skin analysis equipment. In the safety evaluation, some adverse reactions were reported, but no significant were observed directly from cosmetics.

Conclusions

Considering the above results, we have confirmed the possibility of herbal cosmetics containing containing CAPE of Vespae Nidus Extracts.

Keywords: Whitening, Herbal cosmetics, Caffeic acid phenethyl ester, Vespae Nidus, Propolis

Table 1

Clinical Studies on Leg Cramps

Variable	Observed value
	Control (n=20)					Experimental (n=20)					p value**
	mean	SD	median	IQR	p value*	mean	SD	median	IQR	p value*	p value**
육안평가
visit 2	3.800	±1.105	3.500	1.750	-	3.750	±1.070	3.500	1.000	-	0.5641	0.9083
visit 3	3.750	±1.118	4.000	1.750	0.6551	3.550	±0.945	3.000	1.000	0.1571	0.2061	0.5353
visit 4	3.350	±1.309	3.000	2.500	0.0031,#	2.850	±0.745	3.000	1.000	0.0011,#	0.0331,#	0.2313
멜라닌 지수 (기기평가)
visit 2	119.640	±21.902	114.200	27.350	-	119.775	±25.132	118.300	32.525	-	0.8521	0.8293
visit 3	131.850	±26.840	126.500	31.925	0.0011,#	134.010	±26.570	127.550	33.675	0.0012,#	0.6291	0.7663
visit 4	129.190	±24.325	124.750	26.225	0.0261,#	129.895	±27.448	124.200	36.150	0.0132,#	0.7532	0.9324
홍반 지수 (기기평가)
visit 2	321.685	±81.023	335.700	141.800	-	319.260	±74.481	320.750	80.800	-	0.7442	0.9224
visit 3	273.175	±55.931	280.500	89.575	0.0012,#	275.445	±57.821	279.500	83.150	0.0012,#	0.7642	0.9004
visit 4	276.380	±62.236	270.450	92.625	0.0012,#	277.645	±63.709	293.450	74.925	0.0042,#	0.7982	0.9504

# P value<0.05

* P values were compared within each group from baseline.

** P values were compared between groups.

1 P values were derived from Wilcoxon signed rank test.

2 P values were derived from paired t test.

3 P values were derived from Mann-Whitney’s U test.

4 P values were derived from independent t test.

(Shapiro-Wilk’s test was employed for test of normality assumption.)

Table 2

Comparison Difference Form Baseline Between Groups

Variable	Change from baseline(;visit 2)
	Control (n=20)				Experimental (n=20)				p value
	mean	SD	median	IQR	mean	SD	median	IQR	p value
육안평가
visit 3 - 2	−0.050	±0.510	0.000	0.000	−0.200	±0.616	0.000	1.000	0.3171	0.3762
visit 4 - 2	−0.450	±0.510	−0.000	1.000	−0.900	±0.641	−1.000	0.750	0.0291,#	0.0252,#
멜라닌 지수 (기기평가)
visit 3 - 2	12.210	±13.925	10.200	20.375	14.235	±17.170	9.500	22.550	0.9261	0.8922
visit 4 - 2	9.550	±14.379	4.500	25.400	10.120	±16.465	9.850	15.925	0.8302	0.9084
홍반 지수 (기기평가)
visit 3 - 2	−48.510	±43.394	−53.000	58.625	−43.815	±50.739	−39.200	50.375	0.6032	0.7554
visit 4 - 2	−45.305	±53.174	−58.500	85.700	−41.615	±57.263	−32.650	69.625	0.6512	0.8344

# P value<0.05

1 P values were derived from Wilcoxon signed rank test.

2 P values were derived from Mann-Whitney’s U test.

2 P values were derived from paired t test.

4 P values were derived from independent t test.

(Shapiro-Wilk’s test was employed for test of normality assumption.)

Table 3

Analysis Result of Subjective Whitening Improvement

Number (%)	much improved	improved	no change
visit 3	1(5%)	14(70%)	5(25%)
visit 4	0(0%)	11(55%)	9(45%)

Table 4

Analysis Result of Skin Adverse Reactions

No.	Visit	Symptom(Severity)	duration	Note
R7	2–3	erythema(1)	Intermittent (for 2 weeks)
R13	2–3	erythema(1)	5 days
R8	3–4	erythema(2) & itching(1)	3 days
R15	3–4	erythema(2) & itching(2)	4 days	Food related
R15	3–4	erythema(2) & itching(2)	4 days	Food related

* Symtom severity : (0)none, (1)mild, (2)moderate, (3)severe

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