Cha, Kim, Ha, Cheon, and Kim: A Clinical Research about Herbal Cosmetics Containing Caffeic acid phenethyl ester Isolated from Vespae Nidus on the Whitening Effects

Abstract

Objectives

The purpose of this clinical research was to investigate the effects of herbal cosmetics containing Caffeic acid phenethyl ester (CAPE), an ingredient compound of various herbs including Vespae Nidus, on the Whitening Effects.

Methods

A total of 20 subjects who visited Pusan National University Hospital from March 2nd, 2017 to April 11th, 2017 were included. In this study, we evaluated the visual evaluation, the melanin index (M) and erythema index (E) through skin analysis equipment, the subjective whitening improvement analysis, and the adverse reaction according to product use. Statistical analysis was performed with independent t-test and Mann-Whitney’s U test. Statistical significance was achieved if the probability was less than 5% (p<0.05)

Results

As a result of the visual evaluation, it was effective in improving skin whitening. The subjective whitening improvement analysis also showed positive results. However, no statistically significant differences were found between the test and control cosmetics in the melanin index (M) and erythema index (E) through skin analysis equipment. In the safety evaluation, some adverse reactions were reported, but no significant were observed directly from cosmetics.

Conclusions

Considering the above results, we have confirmed the possibility of herbal cosmetics containing containing CAPE of Vespae Nidus Extracts.

Table 1
Clinical Studies on Leg Cramps
Variable Observed value
Control (n=20) Experimental (n=20) p value**
mean SD median IQR p value* mean SD median IQR p value*
육안평가
visit 2 3.800 ±1.105 3.500 1.750 - 3.750 ±1.070 3.500 1.000 - 0.5641 0.9083
visit 3 3.750 ±1.118 4.000 1.750 0.6551 3.550 ±0.945 3.000 1.000 0.1571 0.2061 0.5353
visit 4 3.350 ±1.309 3.000 2.500 0.0031,# 2.850 ±0.745 3.000 1.000 0.0011,# 0.0331,# 0.2313
멜라닌 지수 (기기평가)
visit 2 119.640 ±21.902 114.200 27.350 - 119.775 ±25.132 118.300 32.525 - 0.8521 0.8293
visit 3 131.850 ±26.840 126.500 31.925 0.0011,# 134.010 ±26.570 127.550 33.675 0.0012,# 0.6291 0.7663
visit 4 129.190 ±24.325 124.750 26.225 0.0261,# 129.895 ±27.448 124.200 36.150 0.0132,# 0.7532 0.9324
홍반 지수 (기기평가)
visit 2 321.685 ±81.023 335.700 141.800 - 319.260 ±74.481 320.750 80.800 - 0.7442 0.9224
visit 3 273.175 ±55.931 280.500 89.575 0.0012,# 275.445 ±57.821 279.500 83.150 0.0012,# 0.7642 0.9004
visit 4 276.380 ±62.236 270.450 92.625 0.0012,# 277.645 ±63.709 293.450 74.925 0.0042,# 0.7982 0.9504

# P value<0.05

* P values were compared within each group from baseline.

** P values were compared between groups.

1 P values were derived from Wilcoxon signed rank test.

2 P values were derived from paired t test.

3 P values were derived from Mann-Whitney’s U test.

4 P values were derived from independent t test.

(Shapiro-Wilk’s test was employed for test of normality assumption.)

Table 2
Comparison Difference Form Baseline Between Groups
Variable Change from baseline(;visit 2)
Control (n=20) Experimental (n=20) p value
mean SD median IQR mean SD median IQR
육안평가
visit 3 - 2 −0.050 ±0.510 0.000 0.000 −0.200 ±0.616 0.000 1.000 0.3171 0.3762
visit 4 - 2 −0.450 ±0.510 −0.000 1.000 −0.900 ±0.641 −1.000 0.750 0.0291,# 0.0252,#
멜라닌 지수 (기기평가)
visit 3 - 2 12.210 ±13.925 10.200 20.375 14.235 ±17.170 9.500 22.550 0.9261 0.8922
visit 4 - 2 9.550 ±14.379 4.500 25.400 10.120 ±16.465 9.850 15.925 0.8302 0.9084
홍반 지수 (기기평가)
visit 3 - 2 −48.510 ±43.394 −53.000 58.625 −43.815 ±50.739 −39.200 50.375 0.6032 0.7554
visit 4 - 2 −45.305 ±53.174 −58.500 85.700 −41.615 ±57.263 −32.650 69.625 0.6512 0.8344

# P value<0.05

1 P values were derived from Wilcoxon signed rank test.

2 P values were derived from Mann-Whitney’s U test.

2 P values were derived from paired t test.

4 P values were derived from independent t test.

(Shapiro-Wilk’s test was employed for test of normality assumption.)

Table 3
Analysis Result of Subjective Whitening Improvement
Number (%) much improved improved no change
visit 3 1(5%) 14(70%) 5(25%)
visit 4 0(0%) 11(55%) 9(45%)
Table 4
Analysis Result of Skin Adverse Reactions
No. Visit Symptom(Severity) duration Note
R7 2–3 erythema(1) Intermittent (for 2 weeks)
R13 2–3 erythema(1) 5 days
R8 3–4 erythema(2) & itching(1) 3 days
R15 3–4 erythema(2) & itching(2) 4 days Food related
3–4 erythema(2) & itching(2) 4 days Food related

* Symtom severity : (0)none, (1)mild, (2)moderate, (3)severe

참고문헌

1 Kim KY, Lee NK. Herbal Extracts Research Trend that have Effects on Melanin Production and Control. Kor J Aesthet Cosmetol. 2014; 12:4. 453–61.


2 Park JH, Lee MH. A Study of Skin Color by Melanin Index According to Site, Gestational Age, Birth Weight and Season of Birth in Korean Neonates. J Korean Med Sci. 2005; 20:1. 105–8.
crossref

3 Seo H, Seo GY, Ko SZ, Park YH. Inhibitory Effects of Ethanol Extracts from Polygoni multiflori radix and Cynanchi wilfordii radix on Melanogenesis in Melanoma Cells. J Korean Soc Food Sci Nutr. 2011; 40:1086–91.
crossref

4 Seo EJ, Hong ES, Choi MH, Kim KS, Lee SJ. Antioxidant and skin whitening effects of Ramnus yoshinoi extracts. Korean J Food Sci Technol. 2010; 42:750–4.


5 Lew BL, Ryou JH, Lee Mh. The Anti -melanogenic Effect of Whitening Agent Containing Arbutin and β-Glucosidase. J Soc Cosmet Scientists Korea. 2004; 30:3. 415–8.


6 Jang JS, Jeong JC, Shin HC. Effects of Vespae Nidus on Peroxynitrite Production and Protein Expression of Proinflammatory Mediators. Korean J Oriental Physiology & Pathology. 2007; 21:6. 1499–505.


7 Murtaza G, Karim S, Akram MR, Khan SA, Azhar S, Mumtaz A, et al. Caffeic acid phenethyl ester and therapeutic potentials. Biomed Res Int. 2014; 2014:145342
crossref

8 Erdemli HK, Akyol S, Armutcu F, Akyol O. Antiviral properties of caffeic acid phenethyl ester and its potential application. J Intercult Ethnopharmacol. 2015; 4:4. 344–347.
crossref

9 Lee JY, Choi HJ, Chung TW, Kim CH, Jeong HS, Ha KT. Caffeic acid phenethyl ester inhibits alpha-melanocyte stimulating hormone -induced melanin synthesis through suppressing transactivation activity of microphthalmia -associated transcription factor. J Nat Prod. 2013; 76:8. 1399–405.
crossref

10 Jang DH, Yoo DY. Inhibitory Effect of Persimmon Leaves on Melanin Synthesis and its Action Mechanism in B16F10 cells. J Korean Obstetrics and Gynecology. 2009; 22:2. 43–59.


11 Jung HJ, Do EJ, Lee JS, Park HJ, Oh GS, Kim MR, et al. A Clinical Research about Herbal Cosmetics Containing Momordica charntia L. Extracts on the Anti-wrinkle and Whitening Effects. J Korean Med Ophthalmology and Otolaryngology and Dermatology. 2011; 24:2. 68–78.


TOOLS
PDF Links  PDF Links
Full text via DOI  Full text via DOI
PubReader  PubReader
Download Citation  Download Citation
Supplement  Supplement
  E-Mail
Share:      
METRICS
0
Crossref
136
View
9
Download
Editorial office contact information
3F, #26-27 Gayang-dong, Gangseo-gu Seoul, 157-200 Seoul, Korea
The Society of Korean Medicine
Tel : +82-2-2658-3614   Fax : +82-2-2658-3631   E-mail : skom1953@daum.net
About |  Browse Articles |  Current Issue |  For Authors and Reviewers
powerd by m2community